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SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.

Publication ,  Journal Article
Grieshammer, U; Le Ma, ; Plump, AS; Wang, F; Tessier-Lavigne, M; Martin, GR
Published in: Dev Cell
May 2004

Kidney development occurs in a stereotypic position along the body axis. It begins when a single ureteric bud emerges from the nephric duct in response to GDNF secreted by the adjacent nephrogenic mesenchyme. Posterior restriction of Gdnf expression is considered critical for correct positioning of ureteric bud development. Here we show that mouse mutants lacking either SLIT2 or its receptor ROBO2, molecules known primarily for their function in axon guidance and cell migration, develop supernumerary ureteric buds that remain inappropriately connected to the nephric duct, and that the SLIT2/ROBO2 signal is transduced in the nephrogenic mesenchyme. Furthermore, we show that Gdnf expression is inappropriately maintained in anterior nephrogenic mesenchyme in these mutants. Thus our data identify an intercellular signaling system that restricts, directly or indirectly, the extent of the Gdnf expression domain, thereby precisely positioning the site of kidney induction.

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Published In

Dev Cell

DOI

ISSN

1534-5807

Publication Date

May 2004

Volume

6

Issue

5

Start / End Page

709 / 717

Location

United States

Related Subject Headings

  • Ureter
  • Signal Transduction
  • Receptors, Immunologic
  • Nerve Tissue Proteins
  • Nerve Growth Factors
  • Mutation
  • Mice, Knockout
  • Mice
  • Mesoderm
  • Kidney
 

Citation

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Grieshammer, U., Le Ma, ., Plump, A. S., Wang, F., Tessier-Lavigne, M., & Martin, G. R. (2004). SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell, 6(5), 709–717. https://doi.org/10.1016/s1534-5807(04)00108-x
Grieshammer, Uta, Uta Le Ma, Andrew S. Plump, Fan Wang, Marc Tessier-Lavigne, and Gail R. Martin. “SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.Dev Cell 6, no. 5 (May 2004): 709–17. https://doi.org/10.1016/s1534-5807(04)00108-x.
Grieshammer U, Le Ma, Plump AS, Wang F, Tessier-Lavigne M, Martin GR. SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell. 2004 May;6(5):709–17.
Grieshammer, Uta, et al. “SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.Dev Cell, vol. 6, no. 5, May 2004, pp. 709–17. Pubmed, doi:10.1016/s1534-5807(04)00108-x.
Grieshammer U, Le Ma, Plump AS, Wang F, Tessier-Lavigne M, Martin GR. SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell. 2004 May;6(5):709–717.
Journal cover image

Published In

Dev Cell

DOI

ISSN

1534-5807

Publication Date

May 2004

Volume

6

Issue

5

Start / End Page

709 / 717

Location

United States

Related Subject Headings

  • Ureter
  • Signal Transduction
  • Receptors, Immunologic
  • Nerve Tissue Proteins
  • Nerve Growth Factors
  • Mutation
  • Mice, Knockout
  • Mice
  • Mesoderm
  • Kidney