Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.

Publication ,  Journal Article
Graef, IA; Wang, F; Charron, F; Chen, L; Neilson, J; Tessier-Lavigne, M; Crabtree, GR
Published in: Cell
May 30, 2003

Axon outgrowth is the first step in the formation of neuronal connections, but the pathways that regulate axon extension are still poorly understood. We find that mice deficient in calcineurin-NFAT signaling have dramatic defects in axonal outgrowth, yet have little or no defect in neuronal differentiation or survival. In vitro, sensory and commissural neurons lacking calcineurin function or NFATc2, c3, and c4 are unable to respond to neurotrophins or netrin-1 with efficient axonal outgrowth. Neurotrophins and netrins stimulate calcineurin-dependent nuclear localization of NFATc4 and activation of NFAT-mediated gene transcription in cultured primary neurons. These data indicate that the ability of these embryonic axons to respond to growth factors with rapid outgrowth requires activation of calcineurin/NFAT signaling by these factors. The precise parsing of signals for elongation turning and survival could allow independent control of these processes during development.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

May 30, 2003

Volume

113

Issue

5

Start / End Page

657 / 670

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Transcription Factors
  • Signal Transduction
  • Protein Synthesis Inhibitors
  • Nuclear Proteins
  • Netrin-1
  • Nervous System
  • Nerve Growth Factors
  • NFATC Transcription Factors
  • Mutation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Graef, I. A., Wang, F., Charron, F., Chen, L., Neilson, J., Tessier-Lavigne, M., & Crabtree, G. R. (2003). Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell, 113(5), 657–670. https://doi.org/10.1016/s0092-8674(03)00390-8
Graef, Isabella A., Fan Wang, Frederic Charron, Lei Chen, Joel Neilson, Marc Tessier-Lavigne, and Gerald R. Crabtree. “Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.Cell 113, no. 5 (May 30, 2003): 657–70. https://doi.org/10.1016/s0092-8674(03)00390-8.
Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, et al. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 2003 May 30;113(5):657–70.
Graef, Isabella A., et al. “Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.Cell, vol. 113, no. 5, May 2003, pp. 657–70. Pubmed, doi:10.1016/s0092-8674(03)00390-8.
Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 2003 May 30;113(5):657–670.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

May 30, 2003

Volume

113

Issue

5

Start / End Page

657 / 670

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Transcription Factors
  • Signal Transduction
  • Protein Synthesis Inhibitors
  • Nuclear Proteins
  • Netrin-1
  • Nervous System
  • Nerve Growth Factors
  • NFATC Transcription Factors
  • Mutation