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Smads "freeze" when they ski.

Publication ,  Journal Article
Frederick, JP; Wang, X-F
Published in: Structure
December 2002

The transforming growth factor-beta (TGF-beta) signal is manifest through activated heteromeric Smad complex-mediated transcriptional modulation of target genes that translates into diverse, context-specific biologic effects, such as the potent TGF-beta-initiated cytostatic program. The TGF-beta pathway is effectively antagonized through the direct binding and subsequent repression of activated Smad heteromeric complexes by the Ski family of proto-oncoproteins.

Duke Scholars

Published In

Structure

DOI

ISSN

0969-2126

Publication Date

December 2002

Volume

10

Issue

12

Start / End Page

1607 / 1611

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Trans-Activators
  • Smad Proteins
  • Signal Transduction
  • DNA-Binding Proteins
  • Biophysics
  • 34 Chemical sciences
  • 31 Biological sciences
  • 08 Information and Computing Sciences
  • 06 Biological Sciences
 

Citation

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Frederick, J. P., & Wang, X.-F. (2002). Smads "freeze" when they ski. Structure, 10(12), 1607–1611. https://doi.org/10.1016/s0969-2126(02)00914-0
Frederick, Joshua P., and Xiao-Fan Wang. “Smads "freeze" when they ski.Structure 10, no. 12 (December 2002): 1607–11. https://doi.org/10.1016/s0969-2126(02)00914-0.
Frederick JP, Wang X-F. Smads "freeze" when they ski. Structure. 2002 Dec;10(12):1607–11.
Frederick, Joshua P., and Xiao-Fan Wang. “Smads "freeze" when they ski.Structure, vol. 10, no. 12, Dec. 2002, pp. 1607–11. Pubmed, doi:10.1016/s0969-2126(02)00914-0.
Frederick JP, Wang X-F. Smads "freeze" when they ski. Structure. 2002 Dec;10(12):1607–1611.
Journal cover image

Published In

Structure

DOI

ISSN

0969-2126

Publication Date

December 2002

Volume

10

Issue

12

Start / End Page

1607 / 1611

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Trans-Activators
  • Smad Proteins
  • Signal Transduction
  • DNA-Binding Proteins
  • Biophysics
  • 34 Chemical sciences
  • 31 Biological sciences
  • 08 Information and Computing Sciences
  • 06 Biological Sciences