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A transforming growth factor beta type I receptor that signals to activate gene expression.

Publication ,  Journal Article
Bassing, CH; Yingling, JM; Howe, DJ; Wang, T; He, WW; Gustafson, ML; Shah, P; Donahoe, PK; Wang, XF
Published in: Science
January 7, 1994

Transforming growth factor beta (TGF-beta) is a multifunctional factor that regulates many aspects of cellular functions. TGF-beta signals through a heteromeric complex of the type I and type II TGF-beta receptors. However, the molecular mechanism of signal transduction by this receptor complex remains unresolved. The type II receptor belongs to a transmembrane receptor serine-threonine kinase family. A new member of this receptor family (R4) was identified and shown to be a functional TGF-beta type I receptor on the basis of its ability to restore a TGF-beta-induced gene response in mutant cell lines lacking endogenous type I receptor. Both ligand binding and signaling of the R4 protein were dependent on the presence of a functional type II receptor. The type I receptor has an intrinsic serine-threonine kinase activity, which was essential for signal transduction.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

January 7, 1994

Volume

263

Issue

5143

Start / End Page

87 / 89

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Transfection
  • Signal Transduction
  • Receptors, Transforming Growth Factor beta
  • Receptor, Transforming Growth Factor-beta Type II
  • Rats, Sprague-Dawley
  • Rats
  • Protein Serine-Threonine Kinases
  • Mutagenesis, Site-Directed
  • Genes, Reporter
 

Citation

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Bassing, C. H., Yingling, J. M., Howe, D. J., Wang, T., He, W. W., Gustafson, M. L., … Wang, X. F. (1994). A transforming growth factor beta type I receptor that signals to activate gene expression. Science, 263(5143), 87–89. https://doi.org/10.1126/science.8272871
Bassing, C. H., J. M. Yingling, D. J. Howe, T. Wang, W. W. He, M. L. Gustafson, P. Shah, P. K. Donahoe, and X. F. Wang. “A transforming growth factor beta type I receptor that signals to activate gene expression.Science 263, no. 5143 (January 7, 1994): 87–89. https://doi.org/10.1126/science.8272871.
Bassing CH, Yingling JM, Howe DJ, Wang T, He WW, Gustafson ML, et al. A transforming growth factor beta type I receptor that signals to activate gene expression. Science. 1994 Jan 7;263(5143):87–9.
Bassing, C. H., et al. “A transforming growth factor beta type I receptor that signals to activate gene expression.Science, vol. 263, no. 5143, Jan. 1994, pp. 87–89. Pubmed, doi:10.1126/science.8272871.
Bassing CH, Yingling JM, Howe DJ, Wang T, He WW, Gustafson ML, Shah P, Donahoe PK, Wang XF. A transforming growth factor beta type I receptor that signals to activate gene expression. Science. 1994 Jan 7;263(5143):87–89.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

January 7, 1994

Volume

263

Issue

5143

Start / End Page

87 / 89

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Transfection
  • Signal Transduction
  • Receptors, Transforming Growth Factor beta
  • Receptor, Transforming Growth Factor-beta Type II
  • Rats, Sprague-Dawley
  • Rats
  • Protein Serine-Threonine Kinases
  • Mutagenesis, Site-Directed
  • Genes, Reporter