
A transforming growth factor beta type I receptor that signals to activate gene expression.
Transforming growth factor beta (TGF-beta) is a multifunctional factor that regulates many aspects of cellular functions. TGF-beta signals through a heteromeric complex of the type I and type II TGF-beta receptors. However, the molecular mechanism of signal transduction by this receptor complex remains unresolved. The type II receptor belongs to a transmembrane receptor serine-threonine kinase family. A new member of this receptor family (R4) was identified and shown to be a functional TGF-beta type I receptor on the basis of its ability to restore a TGF-beta-induced gene response in mutant cell lines lacking endogenous type I receptor. Both ligand binding and signaling of the R4 protein were dependent on the presence of a functional type II receptor. The type I receptor has an intrinsic serine-threonine kinase activity, which was essential for signal transduction.
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- Transforming Growth Factor beta
- Transfection
- Signal Transduction
- Receptors, Transforming Growth Factor beta
- Receptor, Transforming Growth Factor-beta Type II
- Rats, Sprague-Dawley
- Rats
- Protein Serine-Threonine Kinases
- Mutagenesis, Site-Directed
- Genes, Reporter
Citation

Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Transforming Growth Factor beta
- Transfection
- Signal Transduction
- Receptors, Transforming Growth Factor beta
- Receptor, Transforming Growth Factor-beta Type II
- Rats, Sprague-Dawley
- Rats
- Protein Serine-Threonine Kinases
- Mutagenesis, Site-Directed
- Genes, Reporter