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Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology.

Publication ,  Journal Article
Zhu, Y; Terry, NG; Woosley, JT; Shaheen, NJ; Wax, A
Published in: Journal of biomedical optics
January 2011

We present a novel Fourier-domain angle-resolved low-coherence interferometry (a /LCI) fiber probe designed for in vivo clinical application in gastrointestinal endoscopy. The a/LCI technique measures the depth-resolved angular scattering distribution to determine the size distribution and optical density of cell nuclei for assessing the health of epithelial tissues. Clinical application is enabled by an endoscopic fiber-optic probe that employs a 2.3-m-long coherent fiber bundle and is compatible with the standard 2.8-mm-diam biopsy channel of a gastroscope. The probe allows for real-time data acquisition by collecting the scattering from multiple angles in parallel, enabled by the Fourier domain approach. The performance of the probe is characterized through measurement of critical parameters. The depth-resolved sizing capability of the system is demonstrated using single- and double-layer microsphere phantoms with subwavelength sizing precision and accuracy achieved. Initial results from a clinical feasibility test are also presented to show in vivo application in the human esophagus.

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Published In

Journal of biomedical optics

DOI

EISSN

1560-2281

ISSN

1083-3668

Publication Date

January 2011

Volume

16

Issue

1

Start / End Page

011003

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Pattern Recognition, Automated
  • Optics
  • Interferometry
  • Image Enhancement
  • Humans
  • Fiber Optic Technology
  • Equipment Failure Analysis
  • Equipment Design
 

Citation

APA
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ICMJE
MLA
NLM
Zhu, Y., Terry, N. G., Woosley, J. T., Shaheen, N. J., & Wax, A. (2011). Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology. Journal of Biomedical Optics, 16(1), 011003. https://doi.org/10.1117/1.3520130
Zhu, Yizheng, Neil G. Terry, John T. Woosley, Nicholas J. Shaheen, and Adam Wax. “Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology.Journal of Biomedical Optics 16, no. 1 (January 2011): 011003. https://doi.org/10.1117/1.3520130.
Zhu, Yizheng, et al. “Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology.Journal of Biomedical Optics, vol. 16, no. 1, Jan. 2011, p. 011003. Epmc, doi:10.1117/1.3520130.

Published In

Journal of biomedical optics

DOI

EISSN

1560-2281

ISSN

1083-3668

Publication Date

January 2011

Volume

16

Issue

1

Start / End Page

011003

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Pattern Recognition, Automated
  • Optics
  • Interferometry
  • Image Enhancement
  • Humans
  • Fiber Optic Technology
  • Equipment Failure Analysis
  • Equipment Design