
CSF CRH in abstinent cocaine-dependent patients.
Alterations in stress responsivity may be important in the vulnerability to become cocaine dependent. Thus, an index of hypothalamic-pituitary-adrenal (HPA) axis function was examined in abstinent cocaine-dependent patients. Cerebrospinal fluid (CSF) concentrations of corticotropin releasing factor (CRH) were determined in 29 abstinent cocaine-dependent patients and 66 normal controls. The results showed that there was no significant difference between the abstinent cocaine-dependent patients and normal controls for CSF CRH. Also, CSF CRH concentrations were not related to cocaine-craving scores in a cue-elicited cocaine-craving procedure. Thus, these data suggest that after protracted abstinence from cocaine there is no marked dysregulation of CRH systems as measured by CSF CRH concentrations.
Duke Scholars
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Substance Withdrawal Syndrome
- Psychiatry
- Pituitary-Adrenal System
- Male
- Hypothalamo-Hypophyseal System
- Hydrocortisone
- Humans
- Follow-Up Studies
- Corticotropin-Releasing Hormone
- Cocaine
Citation

Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Substance Withdrawal Syndrome
- Psychiatry
- Pituitary-Adrenal System
- Male
- Hypothalamo-Hypophyseal System
- Hydrocortisone
- Humans
- Follow-Up Studies
- Corticotropin-Releasing Hormone
- Cocaine