Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP.
Publication
, Journal Article
Kung, AL; Rebel, VI; Bronson, RT; Ch'ng, LE; Sieff, CA; Livingston, DM; Yao, TP
Published in: Genes Dev
February 1, 2000
Mice with monoallelic inactivation of the CBP gene develop highly penetrant, multilineage defects in hematopoietic differentiation and, with advancing age, an increased incidence of hematologic malignancies. The latter are characterized, at least in some cases, by loss of heterozygosity (LOH) at the CBP locus. No such pathology was observed in wild-type or p300 heterozygous null mice of the same age and genetic background. Thus, a full complement of CBP, but not p300, is required for normal hematopoietic differentiation. These results also provide the first experimental evidence for the hypothesis that CBP has tumor-suppressing activity.
Duke Scholars
Published In
Genes Dev
ISSN
0890-9369
Publication Date
February 1, 2000
Volume
14
Issue
3
Start / End Page
272 / 277
Location
United States
Related Subject Headings
- Trans-Activators
- Spleen
- Phenotype
- Nuclear Proteins
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Loss of Heterozygosity
- Heterozygote
- Hematopoiesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Kung, A. L., Rebel, V. I., Bronson, R. T., Ch’ng, L. E., Sieff, C. A., Livingston, D. M., & Yao, T. P. (2000). Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev, 14(3), 272–277.
Kung, A. L., V. I. Rebel, R. T. Bronson, L. E. Ch’ng, C. A. Sieff, D. M. Livingston, and T. P. Yao. “Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP.” Genes Dev 14, no. 3 (February 1, 2000): 272–77.
Kung AL, Rebel VI, Bronson RT, Ch’ng LE, Sieff CA, Livingston DM, et al. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 2000 Feb 1;14(3):272–7.
Kung, A. L., et al. “Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP.” Genes Dev, vol. 14, no. 3, Feb. 2000, pp. 272–77.
Kung AL, Rebel VI, Bronson RT, Ch’ng LE, Sieff CA, Livingston DM, Yao TP. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 2000 Feb 1;14(3):272–277.
Published In
Genes Dev
ISSN
0890-9369
Publication Date
February 1, 2000
Volume
14
Issue
3
Start / End Page
272 / 277
Location
United States
Related Subject Headings
- Trans-Activators
- Spleen
- Phenotype
- Nuclear Proteins
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Loss of Heterozygosity
- Heterozygote
- Hematopoiesis