Skip to main content
Journal cover image

The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

Publication ,  Journal Article
Yao, TP; Ku, G; Zhou, N; Scully, R; Livingston, DM
Published in: Proc Natl Acad Sci U S A
October 1, 1996

p300 and its family member, CREB-binding protein (CBP), function as key transcriptional coactivators by virtue of their interaction with the activated forms of certain transcription factors. In a search for additional cellular targets of p300/CBP, a protein-protein cloning strategy, surprisingly identified SRC-1, a coactivator involved in nuclear hormone receptor transcriptional activity, as a p300/CBP interactive protein. p300 and SRC-1 interact, specifically, in vitro and they also form complexes in vivo. Moreover, we show that SRC-1 encodes a new member of the basic helix-loop-helix-PAS domain family and that it physically interacts with the retinoic acid receptor in response to hormone binding. Together, these results implicate p300 as a component of the retinoic acid signaling pathway, operating, in part, through specific interaction with a nuclear hormone receptor coactivator, SRC-1.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

October 1, 1996

Volume

93

Issue

20

Start / End Page

10626 / 10631

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Trans-Activators
  • Sequence Homology, Amino Acid
  • Sequence Alignment
  • Receptors, Retinoic Acid
  • Protein Binding
  • Nuclear Receptor Coactivator 1
  • Nuclear Proteins
  • Molecular Sequence Data
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yao, T. P., Ku, G., Zhou, N., Scully, R., & Livingston, D. M. (1996). The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci U S A, 93(20), 10626–10631. https://doi.org/10.1073/pnas.93.20.10626
Yao, T. P., G. Ku, N. Zhou, R. Scully, and D. M. Livingston. “The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.Proc Natl Acad Sci U S A 93, no. 20 (October 1, 1996): 10626–31. https://doi.org/10.1073/pnas.93.20.10626.
Yao TP, Ku G, Zhou N, Scully R, Livingston DM. The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10626–31.
Yao, T. P., et al. “The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.Proc Natl Acad Sci U S A, vol. 93, no. 20, Oct. 1996, pp. 10626–31. Pubmed, doi:10.1073/pnas.93.20.10626.
Yao TP, Ku G, Zhou N, Scully R, Livingston DM. The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10626–10631.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

October 1, 1996

Volume

93

Issue

20

Start / End Page

10626 / 10631

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Trans-Activators
  • Sequence Homology, Amino Acid
  • Sequence Alignment
  • Receptors, Retinoic Acid
  • Protein Binding
  • Nuclear Receptor Coactivator 1
  • Nuclear Proteins
  • Molecular Sequence Data