Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response.
Publication
, Journal Article
Zelhof, AC; Yao, TP; Evans, RM; McKeown, M
Published in: Proc Natl Acad Sci U S A
November 7, 1995
In a search for retinoid X receptor-like molecules in Drosophila, we have identified an additional member of the nuclear receptor superfamily, XR78E/F. In the DNA-binding domain, XR78E/F is closely related to the mammalian receptor TR2, as well as to the nuclear receptors Coup-TF and Seven-up. We demonstrate that XR78E/F binds as a homodimer to direct repeats of the sequence AGGTCA. In transient transfection assays, XR78E/F represses ecdysone signaling in a DNA-binding-dependent fashion. XR78E/F has its highest expression in third-instar larvae and prepupae. These experiments suggest that XR78E/F may play a regulatory role in the transcriptional cascade triggered by the hormone ecdysone in Drosophila.
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Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
November 7, 1995
Volume
92
Issue
23
Start / End Page
10477 / 10481
Location
United States
Related Subject Headings
- Transcription Factors
- Tissue Distribution
- Time Factors
- Signal Transduction
- Sequence Analysis, DNA
- Retinoid X Receptors
- Recombinant Proteins
- Receptors, Retinoic Acid
- Protein Binding
- Molecular Sequence Data
Citation
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ICMJE
MLA
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Zelhof, A. C., Yao, T. P., Evans, R. M., & McKeown, M. (1995). Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. Proc Natl Acad Sci U S A, 92(23), 10477–10481. https://doi.org/10.1073/pnas.92.23.10477
Zelhof, A. C., T. P. Yao, R. M. Evans, and M. McKeown. “Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response.” Proc Natl Acad Sci U S A 92, no. 23 (November 7, 1995): 10477–81. https://doi.org/10.1073/pnas.92.23.10477.
Zelhof AC, Yao TP, Evans RM, McKeown M. Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10477–81.
Zelhof, A. C., et al. “Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response.” Proc Natl Acad Sci U S A, vol. 92, no. 23, Nov. 1995, pp. 10477–81. Pubmed, doi:10.1073/pnas.92.23.10477.
Zelhof AC, Yao TP, Evans RM, McKeown M. Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10477–10481.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
November 7, 1995
Volume
92
Issue
23
Start / End Page
10477 / 10481
Location
United States
Related Subject Headings
- Transcription Factors
- Tissue Distribution
- Time Factors
- Signal Transduction
- Sequence Analysis, DNA
- Retinoid X Receptors
- Recombinant Proteins
- Receptors, Retinoic Acid
- Protein Binding
- Molecular Sequence Data