Skip to main content
release_alert
Welcome to the new Scholars 3.0! Read about new features and let us know what you think.
cancel

Alternative translation initiation site usage results in two structurally distinct forms of Pit-1.

Publication ,  Journal Article
Voss, JW; Yao, TP; Rosenfeld, MG
Published in: J Biol Chem
July 15, 1991

Pit-1 is a pituitary-specific transcription factor that plays a critical role in the normal development of the anterior pituitary gland. Previous analyses have shown that this protein exists in the rat pituitary gland and in rat pituitary-derived cell lines as two forms of relative molecular mass 33 and 31 kDa. This aspect of Pit-1 expression has been conserved throughout the evolution from rodents to humans. Here, we determine the origin of these structurally distinct forms of Pit-1 protein and find that these arise as a consequence of the alternative usage of translation initiation sites present in Pit-1 mRNA.

Duke Scholars

Published In

J Biol Chem

ISSN

0021-9258

Publication Date

July 15, 1991

Volume

266

Issue

20

Start / End Page

12832 / 12835

Location

United States

Related Subject Headings

  • Transfection
  • Transcription, Genetic
  • Transcription Factors
  • Transcription Factor Pit-1
  • Rats
  • Protein Biosynthesis
  • Pituitary Gland, Anterior
  • Peptides
  • Mutagenesis, Site-Directed
  • Molecular Sequence Data
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Voss, J. W., Yao, T. P., & Rosenfeld, M. G. (1991). Alternative translation initiation site usage results in two structurally distinct forms of Pit-1. J Biol Chem, 266(20), 12832–12835.
Voss, J. W., T. P. Yao, and M. G. Rosenfeld. “Alternative translation initiation site usage results in two structurally distinct forms of Pit-1.J Biol Chem 266, no. 20 (July 15, 1991): 12832–35.
Voss JW, Yao TP, Rosenfeld MG. Alternative translation initiation site usage results in two structurally distinct forms of Pit-1. J Biol Chem. 1991 Jul 15;266(20):12832–5.
Voss, J. W., et al. “Alternative translation initiation site usage results in two structurally distinct forms of Pit-1.J Biol Chem, vol. 266, no. 20, July 1991, pp. 12832–35.
Voss JW, Yao TP, Rosenfeld MG. Alternative translation initiation site usage results in two structurally distinct forms of Pit-1. J Biol Chem. 1991 Jul 15;266(20):12832–12835.

Published In

J Biol Chem

ISSN

0021-9258

Publication Date

July 15, 1991

Volume

266

Issue

20

Start / End Page

12832 / 12835

Location

United States

Related Subject Headings

  • Transfection
  • Transcription, Genetic
  • Transcription Factors
  • Transcription Factor Pit-1
  • Rats
  • Protein Biosynthesis
  • Pituitary Gland, Anterior
  • Peptides
  • Mutagenesis, Site-Directed
  • Molecular Sequence Data