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Engineering multicellular systems by cell-cell communication.

Publication ,  Journal Article
Pai, A; Tanouchi, Y; Collins, CH; You, L
Published in: Current opinion in biotechnology
August 2009

Synthetic biology encompasses the design of new biological parts and systems as well as the modulation of existing biological networks to generate novel functions. In recent years, increasing emphasis has been placed on the engineering of population-level behaviors using cell-cell communication. From the engineering perspective, cell-cell communication serves as a versatile regulatory module that enables coordination among cells in and between populations and facilitates the generation of reliable dynamics. In addition to exploring biological 'design principles' via the construction of increasingly complex dynamics, communication-based synthetic systems can be used as well-defined model systems to study ecological and social interactions such as competition, cooperation, and predation. Here we discuss the dynamic properties of cell-cell communication modules, how they can be engineered for synthetic circuit design, and applications of these systems.

Duke Scholars

Published In

Current opinion in biotechnology

DOI

EISSN

1879-0429

ISSN

0958-1669

Publication Date

August 2009

Volume

20

Issue

4

Start / End Page

461 / 470

Related Subject Headings

  • Models, Theoretical
  • Genes, Bacterial
  • Cell Communication
  • Biotechnology
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology
  • 10 Technology
  • 09 Engineering
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pai, A., Tanouchi, Y., Collins, C. H., & You, L. (2009). Engineering multicellular systems by cell-cell communication. Current Opinion in Biotechnology, 20(4), 461–470. https://doi.org/10.1016/j.copbio.2009.08.006
Pai, Anand, Yu Tanouchi, Cynthia H. Collins, and Lingchong You. “Engineering multicellular systems by cell-cell communication.Current Opinion in Biotechnology 20, no. 4 (August 2009): 461–70. https://doi.org/10.1016/j.copbio.2009.08.006.
Pai A, Tanouchi Y, Collins CH, You L. Engineering multicellular systems by cell-cell communication. Current opinion in biotechnology. 2009 Aug;20(4):461–70.
Pai, Anand, et al. “Engineering multicellular systems by cell-cell communication.Current Opinion in Biotechnology, vol. 20, no. 4, Aug. 2009, pp. 461–70. Epmc, doi:10.1016/j.copbio.2009.08.006.
Pai A, Tanouchi Y, Collins CH, You L. Engineering multicellular systems by cell-cell communication. Current opinion in biotechnology. 2009 Aug;20(4):461–470.
Journal cover image

Published In

Current opinion in biotechnology

DOI

EISSN

1879-0429

ISSN

0958-1669

Publication Date

August 2009

Volume

20

Issue

4

Start / End Page

461 / 470

Related Subject Headings

  • Models, Theoretical
  • Genes, Bacterial
  • Cell Communication
  • Biotechnology
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology
  • 10 Technology
  • 09 Engineering
  • 06 Biological Sciences