Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Numerical simulations of transcorneal tranport of ethacrynic acid

Publication ,  Journal Article
Lin, CW; Yuan, F
Published in: Proceedings of the 2005 Summer Bioengineering Conference
December 1, 2005

Potential trabecular meshwork (TM) drugs can be delivered with a lower concentration on the cornea surface over a long period of time for reducing the induced corneal toxicity. To determine the concentration of drugs that can be achieved in the TM, we developed a mathematical model to simulate axisymmetric transport of ethacrynic acid (ECA) from the cornea surface to the TM in a human eye. The results showed that the concentration of ECA could reach the therapeutic level at the TM site while the concentration of ECA on the cornea surface was maintained at an optimal level (75 μM) below the toxicity threshold. These results can be used to guide the design of controlled drug release devices.

Duke Scholars

Published In

Proceedings of the 2005 Summer Bioengineering Conference

Publication Date

December 1, 2005

Volume

2005

Start / End Page

289 / 290
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lin, C. W., & Yuan, F. (2005). Numerical simulations of transcorneal tranport of ethacrynic acid. Proceedings of the 2005 Summer Bioengineering Conference, 2005, 289–290.
Lin, C. W., and F. Yuan. “Numerical simulations of transcorneal tranport of ethacrynic acid.” Proceedings of the 2005 Summer Bioengineering Conference 2005 (December 1, 2005): 289–90.
Lin CW, Yuan F. Numerical simulations of transcorneal tranport of ethacrynic acid. Proceedings of the 2005 Summer Bioengineering Conference. 2005 Dec 1;2005:289–90.
Lin, C. W., and F. Yuan. “Numerical simulations of transcorneal tranport of ethacrynic acid.” Proceedings of the 2005 Summer Bioengineering Conference, vol. 2005, Dec. 2005, pp. 289–90.
Lin CW, Yuan F. Numerical simulations of transcorneal tranport of ethacrynic acid. Proceedings of the 2005 Summer Bioengineering Conference. 2005 Dec 1;2005:289–290.

Published In

Proceedings of the 2005 Summer Bioengineering Conference

Publication Date

December 1, 2005

Volume

2005

Start / End Page

289 / 290