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Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.

Publication ,  Journal Article
Shin, J; O'Brien, TF; Grayson, JM; Zhong, X-P
Published in: J Immunol
March 1, 2012

The manipulation of signals downstream of the TCR can have profound consequences for T cell development, function, and homeostasis. Diacylglycerol (DAG) produced after TCR stimulation functions as a secondary messenger and mediates the signaling to Ras-MEK-Erk and NF-κB pathways in T cells. DAG kinases (DGKs) convert DAG into phosphatidic acid, resulting in termination of DAG signaling. In this study, we demonstrate that DAG metabolism by DGKs can serve a crucial function in viral clearance upon lymphocytic choriomeningitis virus infection. Ag-specific CD8(+) T cells from DGKα(-/-) and DGKζ(-/-) mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK-deficient memory CD8(+) T cells exhibit impaired expansion after rechallenge. Thus, DGK activity plays opposing roles in the expansion of CD8(+) T cells during the primary and memory phases of the immune response, whereas consistently inhibiting antiviral cytokine production.

Duke Scholars

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

March 1, 2012

Volume

188

Issue

5

Start / End Page

2111 / 2117

Location

United States

Related Subject Headings

  • Mice, Transgenic
  • Mice, Knockout
  • Mice
  • Lymphocytic choriomeningitis virus
  • Lymphocytic Choriomeningitis
  • Immunology
  • Immunologic Memory
  • Epitopes, T-Lymphocyte
  • Down-Regulation
  • Disease Models, Animal
 

Citation

APA
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ICMJE
MLA
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Shin, J., O’Brien, T. F., Grayson, J. M., & Zhong, X.-P. (2012). Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases. J Immunol, 188(5), 2111–2117. https://doi.org/10.4049/jimmunol.1102265
Shin, Jinwook, Thomas F. O’Brien, Jason M. Grayson, and Xiao-Ping Zhong. “Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.J Immunol 188, no. 5 (March 1, 2012): 2111–17. https://doi.org/10.4049/jimmunol.1102265.
Shin J, O’Brien TF, Grayson JM, Zhong X-P. Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases. J Immunol. 2012 Mar 1;188(5):2111–7.
Shin, Jinwook, et al. “Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.J Immunol, vol. 188, no. 5, Mar. 2012, pp. 2111–17. Pubmed, doi:10.4049/jimmunol.1102265.
Shin J, O’Brien TF, Grayson JM, Zhong X-P. Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases. J Immunol. 2012 Mar 1;188(5):2111–2117.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

March 1, 2012

Volume

188

Issue

5

Start / End Page

2111 / 2117

Location

United States

Related Subject Headings

  • Mice, Transgenic
  • Mice, Knockout
  • Mice
  • Lymphocytic choriomeningitis virus
  • Lymphocytic Choriomeningitis
  • Immunology
  • Immunologic Memory
  • Epitopes, T-Lymphocyte
  • Down-Regulation
  • Disease Models, Animal