Assessment of age-related changes in left ventricular structure and function by freehand three-dimensional echocardiography.

To determine age-related changes in left ventricular (LV) structure and function, the authors used freehand three-dimensional echocardiography, a previously validated tomographic technique, to measure LV mass, volumes, and derived parameters in 94 sedentary, but ambulatory and clinically healthy, adult male and female volunteers aged 20-94. LV volumes and mass were significantly greater in men than in women (p<0.001) and remained greater after adjustment for body surface area and height (p<0.05). Declines in end-diastolic and stroke volumes with age were reduced or absent after accounting for body size. By multivariate analysis, age accounted for only about 6%-11% of the variance among LV volumes and mass, in comparison with body surface area and gender, which accounted jointly for about 46%-77% of the variance. In conclusion, changes occur in LV structure and function with normal aging, but these changes are relatively minor when body size and gender are taken into account.

Duke Scholars

Author Michel Georges Khouri Medicine, Cardiology