Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.
Publication
, Journal Article
Long, K; Boyce, M; Lin, H; Yuan, J; Ma, D
Published in: Bioorg Med Chem Lett
September 1, 2005
The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification.
Duke Scholars
Published In
Bioorg Med Chem Lett
DOI
ISSN
0960-894X
Publication Date
September 1, 2005
Volume
15
Issue
17
Start / End Page
3849 / 3852
Location
England
Related Subject Headings
- Thiourea
- Structure-Activity Relationship
- Rats
- Protective Agents
- PC12 Cells
- Medicinal & Biomolecular Chemistry
- Dose-Response Relationship, Drug
- Cinnamates
- Cell Survival
- Biotinylation
Citation
APA
Chicago
ICMJE
MLA
NLM
Long, K., Boyce, M., Lin, H., Yuan, J., & Ma, D. (2005). Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg Med Chem Lett, 15(17), 3849–3852. https://doi.org/10.1016/j.bmcl.2005.05.120
Long, Kai, Michael Boyce, He Lin, Junying Yuan, and Dawei Ma. “Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.” Bioorg Med Chem Lett 15, no. 17 (September 1, 2005): 3849–52. https://doi.org/10.1016/j.bmcl.2005.05.120.
Long K, Boyce M, Lin H, Yuan J, Ma D. Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3849–52.
Long, Kai, et al. “Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.” Bioorg Med Chem Lett, vol. 15, no. 17, Sept. 2005, pp. 3849–52. Pubmed, doi:10.1016/j.bmcl.2005.05.120.
Long K, Boyce M, Lin H, Yuan J, Ma D. Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3849–3852.
Published In
Bioorg Med Chem Lett
DOI
ISSN
0960-894X
Publication Date
September 1, 2005
Volume
15
Issue
17
Start / End Page
3849 / 3852
Location
England
Related Subject Headings
- Thiourea
- Structure-Activity Relationship
- Rats
- Protective Agents
- PC12 Cells
- Medicinal & Biomolecular Chemistry
- Dose-Response Relationship, Drug
- Cinnamates
- Cell Survival
- Biotinylation