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Caspases: an ancient cellular sword of Damocles.

Publication ,  Journal Article
Boyce, M; Degterev, A; Yuan, J
Published in: Cell Death Differ
January 2004
Published version (DOI) Open Access Copy (Duke) Link to item

Caspases are a family of cysteine proteases homologous to the Caenorhabditis elegans programmed cell death gene product CED-3. Caspases and their distant relatives, meta- and paracaspases, have been found in phylogenetically distant nonmetazoan groups, including plants, fungi and prokaryotes. This review summarizes the current information on the mechanisms and functions of non-mammalian caspases and their relatives in apoptotic and nonapoptotic processes, and explores the possible evolutionary origin of the caspase family.

Duke Scholars

Michael Scott Boyce
Author Michael Scott Boyce Biochemistry

Published In

Cell Death Differ

DOI

10.1038/sj.cdd.4401339

ISSN

1350-9047

Publication Date

January 2004

Volume

11

Issue

1

Start / End Page

29 / 37

Location

England

Related Subject Headings

  • Humans
  • Evolution, Molecular
  • Caspases
  • Caenorhabditis elegans Proteins
  • Biochemistry & Molecular Biology
  • Apoptosis
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Boyce, M., Degterev, A., & Yuan, J. (2004). Caspases: an ancient cellular sword of Damocles. Cell Death Differ, 11(1), 29–37. https://doi.org/10.1038/sj.cdd.4401339
Boyce, M., A. Degterev, and J. Yuan. “Caspases: an ancient cellular sword of Damocles.” Cell Death Differ 11, no. 1 (January 2004): 29–37. https://doi.org/10.1038/sj.cdd.4401339.
Boyce M, Degterev A, Yuan J. Caspases: an ancient cellular sword of Damocles. Cell Death Differ. 2004 Jan;11(1):29–37.
Boyce, M., et al. “Caspases: an ancient cellular sword of Damocles.” Cell Death Differ, vol. 11, no. 1, Jan. 2004, pp. 29–37. Pubmed, doi:10.1038/sj.cdd.4401339.
Boyce M, Degterev A, Yuan J. Caspases: an ancient cellular sword of Damocles. Cell Death Differ. 2004 Jan;11(1):29–37.

Published In

Cell Death Differ

DOI

10.1038/sj.cdd.4401339

ISSN

1350-9047

Publication Date

January 2004

Volume

11

Issue

1

Start / End Page

29 / 37

Location

England

Related Subject Headings

  • Humans
  • Evolution, Molecular
  • Caspases
  • Caenorhabditis elegans Proteins
  • Biochemistry & Molecular Biology
  • Apoptosis
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences