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Potential predictive biomarkers for individualizing treatment for men with castration-resistant prostate cancer.

Publication ,  Journal Article
Bitting, RL; Armstrong, AJ
Published in: Cancer J
2013

With the surge in therapeutic options for men with castration-resistant prostate cancer (CRPC) comes increasingly complicated treatment decision making, highlighting the need for biomarkers that can identify appropriate patients for specific treatments and accurately assess disease response. Predictive biomarkers are factors related to the disease or the host that are associated with improvements in outcomes, such as survival, due to specific therapies. Such biomarkers have become of paramount importance in oncology to maximize the benefits of novel systemic agents while minimizing harm to individual patients and the costs to society. Given the number of newly approved and expensive systemic therapies, including novel hormonal therapies, chemotherapies, immunotherapies, and bone microenvironment-targeting therapies, predictive biomarkers are needed to give physicians a more rational sense of matching the right patient to the right therapy sequence at a given time. There are currently no validated predictive biomarkers in CRPC. We discuss potential predictive biomarkers in men with CRPC and how these may be developed in the context of therapeutic clinical trials.

Duke Scholars

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Published In

Cancer J

DOI

EISSN

1540-336X

Publication Date

2013

Volume

19

Issue

1

Start / End Page

25 / 33

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Prostatic Neoplasms
  • Prognosis
  • Precision Medicine
  • Orchiectomy
  • Oncology & Carcinogenesis
  • Neoplastic Cells, Circulating
  • Male
  • Immunotherapy
  • Humans
 

Citation

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Bitting, R. L., & Armstrong, A. J. (2013). Potential predictive biomarkers for individualizing treatment for men with castration-resistant prostate cancer. Cancer J, 19(1), 25–33. https://doi.org/10.1097/PPO.0b013e31827e0b9c
Bitting, Rhonda L., and Andrew J. Armstrong. “Potential predictive biomarkers for individualizing treatment for men with castration-resistant prostate cancer.Cancer J 19, no. 1 (2013): 25–33. https://doi.org/10.1097/PPO.0b013e31827e0b9c.
Bitting, Rhonda L., and Andrew J. Armstrong. “Potential predictive biomarkers for individualizing treatment for men with castration-resistant prostate cancer.Cancer J, vol. 19, no. 1, 2013, pp. 25–33. Pubmed, doi:10.1097/PPO.0b013e31827e0b9c.

Published In

Cancer J

DOI

EISSN

1540-336X

Publication Date

2013

Volume

19

Issue

1

Start / End Page

25 / 33

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Prostatic Neoplasms
  • Prognosis
  • Precision Medicine
  • Orchiectomy
  • Oncology & Carcinogenesis
  • Neoplastic Cells, Circulating
  • Male
  • Immunotherapy
  • Humans