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Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol.

Publication ,  Journal Article
Calton, JL; Wilson, WA; Moore, SD
Published in: J Pharmacol Exp Ther
December 1998

Previous studies have indicated that ethanol (EtOH) has a relatively specific effect on excitatory synaptic transmission by inhibiting function of the N-methyl-D-aspartate receptor. We have found that EtOH potently inhibits N-methyl-D-aspartate-mediated synaptic currents in the basolateral amygdala, a brain region associated with actions of anxiolytic agents such as EtOH. This inhibitory effect of EtOH requires the presence of magnesium (Mg++). The dependence of the effect of EtOH on the presence of Mg++ suggests a possible molecular site of the action of EtOH in the vicinity of Mg++ binding sites on the N-methyl-D-aspartate receptor-channel complex. Because EtOH consumption may result in reductions in free brain Mg++, this dynamic interaction between EtOH and Mg++ may have important implications for understanding the behavioral effects of EtOH.

Duke Scholars

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

December 1998

Volume

287

Issue

3

Start / End Page

1015 / 1019

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Receptors, N-Methyl-D-Aspartate
  • Rats, Sprague-Dawley
  • Rats
  • Pharmacology & Pharmacy
  • Male
  • Magnesium
  • In Vitro Techniques
  • Glutamic Acid
  • Ethanol
 

Citation

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MLA
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Calton, J. L., Wilson, W. A., & Moore, S. D. (1998). Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol. J Pharmacol Exp Ther, 287(3), 1015–1019.
Calton, J. L., W. A. Wilson, and S. D. Moore. “Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol.J Pharmacol Exp Ther 287, no. 3 (December 1998): 1015–19.
Calton JL, Wilson WA, Moore SD. Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol. J Pharmacol Exp Ther. 1998 Dec;287(3):1015–9.
Calton, J. L., et al. “Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol.J Pharmacol Exp Ther, vol. 287, no. 3, Dec. 1998, pp. 1015–19.
Calton JL, Wilson WA, Moore SD. Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol. J Pharmacol Exp Ther. 1998 Dec;287(3):1015–1019.

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

December 1998

Volume

287

Issue

3

Start / End Page

1015 / 1019

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Receptors, N-Methyl-D-Aspartate
  • Rats, Sprague-Dawley
  • Rats
  • Pharmacology & Pharmacy
  • Male
  • Magnesium
  • In Vitro Techniques
  • Glutamic Acid
  • Ethanol