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Phylogeny of Toll-like receptor signaling: adapting the innate response.

Publication ,  Journal Article
Roach, JM; Racioppi, L; Jones, CD; Masci, AM
Published in: PLoS One
2013

The Toll-like receptors represent a largely evolutionarily conserved pathogen recognition machinery responsible for recognition of bacterial, fungal, protozoan, and viral pathogen associated microbial patterns and initiation of inflammatory response. Structurally the Toll-like receptors are comprised of an extracellular leucine rich repeat domain and a cytoplasmic Toll/Interleukin 1 receptor domain. Recognition takes place in the extracellular domain where as the cytoplasmic domain triggers a complex signal network required to sustain appropriate immune response. Signal transduction is regulated by the recruitment of different intracellular adaptors. The Toll-like receptors can be grouped depending on the usage of the adaptor, MyD88, into MyD88-dependent and MyD88 independent subsets. Herein, we present a unique phylogenetic analysis of domain regions of these receptors and their cognate signaling adaptor molecules. Although previously unclear from the phylogeny of full length receptors, these analyses indicate a separate evolutionary origin for the MyD88-dependent and MyD88-independent signaling pathway and provide evidence of a common ancestor for the vertebrate and invertebrate orthologs of the adaptor molecule MyD88. Together these observations suggest a very ancient origin of the MyD88-dependent pathway Additionally we show that early duplications gave rise to several adaptor molecule families. In some cases there is also strong pattern of parallel duplication between adaptor molecules and their corresponding TLR. Our results further support the hypothesis that phylogeny of specific domains involved in signaling pathway can shed light on key processes that link innate to adaptive immune response.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

1

Start / End Page

e54156

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Toll-Like Receptor 4
  • Signal Transduction
  • Receptors, Interleukin-1
  • Phylogeny
  • Myeloid Differentiation Factor 88
  • Immunity, Innate
  • General Science & Technology
  • Gene Duplication
  • Evolution, Molecular
 

Citation

APA
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MLA
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Roach, J. M., Racioppi, L., Jones, C. D., & Masci, A. M. (2013). Phylogeny of Toll-like receptor signaling: adapting the innate response. PLoS One, 8(1), e54156. https://doi.org/10.1371/journal.pone.0054156
Roach, Jeffrey M., Luigi Racioppi, Corbin D. Jones, and Anna Maria Masci. “Phylogeny of Toll-like receptor signaling: adapting the innate response.PLoS One 8, no. 1 (2013): e54156. https://doi.org/10.1371/journal.pone.0054156.
Roach JM, Racioppi L, Jones CD, Masci AM. Phylogeny of Toll-like receptor signaling: adapting the innate response. PLoS One. 2013;8(1):e54156.
Roach, Jeffrey M., et al. “Phylogeny of Toll-like receptor signaling: adapting the innate response.PLoS One, vol. 8, no. 1, 2013, p. e54156. Pubmed, doi:10.1371/journal.pone.0054156.
Roach JM, Racioppi L, Jones CD, Masci AM. Phylogeny of Toll-like receptor signaling: adapting the innate response. PLoS One. 2013;8(1):e54156.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

1

Start / End Page

e54156

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Toll-Like Receptor 4
  • Signal Transduction
  • Receptors, Interleukin-1
  • Phylogeny
  • Myeloid Differentiation Factor 88
  • Immunity, Innate
  • General Science & Technology
  • Gene Duplication
  • Evolution, Molecular