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Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure.

Publication ,  Journal Article
DeBaun, MR; Sarnaik, SA; Rodeghier, MJ; Minniti, CP; Howard, TH; Iyer, RV; Inusa, B; Telfer, PT; Kirby-Allen, M; Quinn, CT; Bernaudin, F ...
Published in: Blood
April 2012

The most common form of neurologic injury in sickle cell anemia (SCA) is silent cerebral infarction (SCI). In the Silent Cerebral Infarct Multi-Center Clinical Trial, we sought to identify risk factors associated with SCI. In this cross-sectional study, we evaluated the clinical history and baseline laboratory values and performed magnetic resonance imaging of the brain in participants with SCA (HbSS or HbSβ° thalassemia) between the ages of 5 and 15 years with no history of overt stroke or seizures. Neuroradiology and neurology committees adjudicated the presence of SCI. SCIs were diagnosed in 30.8% (251 of 814) participants who completed all evaluations and had valid data on all prespecified demographic and clinical covariates. The mean age of the participants was 9.1 years, with 413 males (50.7%). In a multivariable logistic regression analysis, lower baseline hemoglobin concentration (P < .001), higher baseline systolic blood pressure (P = .018), and male sex (P = .030) were statistically significantly associated with an increased risk of an SCI. Hemoglobin concentration and systolic blood pressure are risk factors for SCI in children with SCA and may be therapeutic targets for decreasing the risk of SCI. This study is registered at www.clinicaltrials.gov as #NCT00072761.

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Published In

Blood

DOI

EISSN

1528-0020

ISSN

0006-4971

Publication Date

April 2012

Volume

119

Issue

16

Start / End Page

3684 / 3690

Related Subject Headings

  • beta-Thalassemia
  • Sex Distribution
  • Risk Factors
  • Multivariate Analysis
  • Male
  • Magnetic Resonance Imaging
  • Immunology
  • Humans
  • Hemoglobin, Sickle
  • Female
 

Citation

APA
Chicago
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MLA
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DeBaun, M. R., Sarnaik, S. A., Rodeghier, M. J., Minniti, C. P., Howard, T. H., Iyer, R. V., … Casella, J. F. (2012). Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure. Blood, 119(16), 3684–3690. https://doi.org/10.1182/blood-2011-05-349621
DeBaun, Michael R., Sharada A. Sarnaik, Mark J. Rodeghier, Caterina P. Minniti, Thomas H. Howard, Rathi V. Iyer, Baba Inusa, et al. “Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure.Blood 119, no. 16 (April 2012): 3684–90. https://doi.org/10.1182/blood-2011-05-349621.
DeBaun MR, Sarnaik SA, Rodeghier MJ, Minniti CP, Howard TH, Iyer RV, et al. Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure. Blood. 2012 Apr;119(16):3684–90.
DeBaun, Michael R., et al. “Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure.Blood, vol. 119, no. 16, Apr. 2012, pp. 3684–90. Epmc, doi:10.1182/blood-2011-05-349621.
DeBaun MR, Sarnaik SA, Rodeghier MJ, Minniti CP, Howard TH, Iyer RV, Inusa B, Telfer PT, Kirby-Allen M, Quinn CT, Bernaudin F, Airewele G, Woods GM, Panepinto JA, Fuh B, Kwiatkowski JK, King AA, Rhodes MM, Thompson AA, Heiny ME, Redding-Lallinger RC, Kirkham FJ, Sabio H, Gonzalez CE, Saccente SL, Kalinyak KA, Strouse JJ, Fixler JM, Gordon MO, Miller JP, Noetzel MJ, Ichord RN, Casella JF. Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure. Blood. 2012 Apr;119(16):3684–3690.

Published In

Blood

DOI

EISSN

1528-0020

ISSN

0006-4971

Publication Date

April 2012

Volume

119

Issue

16

Start / End Page

3684 / 3690

Related Subject Headings

  • beta-Thalassemia
  • Sex Distribution
  • Risk Factors
  • Multivariate Analysis
  • Male
  • Magnetic Resonance Imaging
  • Immunology
  • Humans
  • Hemoglobin, Sickle
  • Female