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Endothelial Cell Vascular Smooth Muscle Cell Co-Culture Assay For High Throughput Screening Assays For Discovery of Anti-Angiogenesis Agents and Other Therapeutic Molecules.

Publication ,  Journal Article
Truskey, GA
Published in: International journal of high throughput screening
October 2010

Drug development for many diseases would be aided greatly by accurate in vitro model systems that replicate key elements of in vivo physiology. The recent development of co-culture systems of endothelial cells and vascular smooth muscle cells can be extended to high throughput systems for the identification of compounds for angiogenesis, vascular repair and hypertension. In this review, the various co-culture systems are reviewed and biological interactions between endothelial cells and vascular smooth muscle cells are discussed. Key considerations in the design of high throughput systems are presented and selected examples are discussed.

Duke Scholars

Published In

International journal of high throughput screening

DOI

EISSN

1179-1381

ISSN

1179-1381

Publication Date

October 2010

Volume

2010

Issue

1

Start / End Page

171 / 181

Related Subject Headings

  • 3401 Analytical chemistry
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
  • 0301 Analytical Chemistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Truskey, G. A. (2010). Endothelial Cell Vascular Smooth Muscle Cell Co-Culture Assay For High Throughput Screening Assays For Discovery of Anti-Angiogenesis Agents and Other Therapeutic Molecules. International Journal of High Throughput Screening, 2010(1), 171–181. https://doi.org/10.2147/ijhts.s13459
Truskey, George A. “Endothelial Cell Vascular Smooth Muscle Cell Co-Culture Assay For High Throughput Screening Assays For Discovery of Anti-Angiogenesis Agents and Other Therapeutic Molecules.International Journal of High Throughput Screening 2010, no. 1 (October 2010): 171–81. https://doi.org/10.2147/ijhts.s13459.
Truskey, George A. “Endothelial Cell Vascular Smooth Muscle Cell Co-Culture Assay For High Throughput Screening Assays For Discovery of Anti-Angiogenesis Agents and Other Therapeutic Molecules.International Journal of High Throughput Screening, vol. 2010, no. 1, Oct. 2010, pp. 171–81. Epmc, doi:10.2147/ijhts.s13459.

Published In

International journal of high throughput screening

DOI

EISSN

1179-1381

ISSN

1179-1381

Publication Date

October 2010

Volume

2010

Issue

1

Start / End Page

171 / 181

Related Subject Headings

  • 3401 Analytical chemistry
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
  • 0301 Analytical Chemistry