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Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate.

Publication ,  Journal Article
Hsu, S-HC; Zhang, X; Cheng, S; Wunder, JS; Hui, C-C; Alman, BA
Published in: J Biol Chem
October 19, 2012

Growth plate chondrocytes undergo a coordinated process of differentiation, regulating long bone growth. Parathyroid hormone-like hormone (Pthlh) inhibits hypertrophic differentiation in the growth plate chondrocytes and reduces Hedgehog (Hh) signaling. In mice lacking the Hh mediator Suppressor of fused (Sufu), Pthlh treatment resulted in the up-regulation of Hh activity and an increased number of hypertrophic chondrocytes. Furthermore, Pthlh increased Sufu protein levels, and in chondrocytes lacking Sufu, it was unable to process Hh-regulated Gli transcription factors. Pthlh regulates chondrocyte differentiation and Gli activity in a Sufu-dependent manner, with Sufu acting as a molecular switch in its regulation of differentiation.

Duke Scholars

Published In

J Biol Chem

DOI

EISSN

1083-351X

Publication Date

October 19, 2012

Volume

287

Issue

43

Start / End Page

36222 / 36228

Location

United States

Related Subject Headings

  • Zinc Finger Protein GLI1
  • Signal Transduction
  • Repressor Proteins
  • Parathyroid Hormone-Related Protein
  • Mice, Mutant Strains
  • Mice
  • Kruppel-Like Transcription Factors
  • Hedgehog Proteins
  • Growth Plate
  • Chondrocytes
 

Citation

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Hsu, S.-H., Zhang, X., Cheng, S., Wunder, J. S., Hui, C.-C., & Alman, B. A. (2012). Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate. J Biol Chem, 287(43), 36222–36228. https://doi.org/10.1074/jbc.M112.382275
Hsu, Shu-Hsuan C., Xiaoyun Zhang, Steven Cheng, Jay S. Wunder, Chi-Chung Hui, and Benjamin A. Alman. “Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate.J Biol Chem 287, no. 43 (October 19, 2012): 36222–28. https://doi.org/10.1074/jbc.M112.382275.
Hsu S-HC, Zhang X, Cheng S, Wunder JS, Hui C-C, Alman BA. Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate. J Biol Chem. 2012 Oct 19;287(43):36222–8.
Hsu, Shu-Hsuan C., et al. “Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate.J Biol Chem, vol. 287, no. 43, Oct. 2012, pp. 36222–28. Pubmed, doi:10.1074/jbc.M112.382275.
Hsu S-HC, Zhang X, Cheng S, Wunder JS, Hui C-C, Alman BA. Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate. J Biol Chem. 2012 Oct 19;287(43):36222–36228.

Published In

J Biol Chem

DOI

EISSN

1083-351X

Publication Date

October 19, 2012

Volume

287

Issue

43

Start / End Page

36222 / 36228

Location

United States

Related Subject Headings

  • Zinc Finger Protein GLI1
  • Signal Transduction
  • Repressor Proteins
  • Parathyroid Hormone-Related Protein
  • Mice, Mutant Strains
  • Mice
  • Kruppel-Like Transcription Factors
  • Hedgehog Proteins
  • Growth Plate
  • Chondrocytes