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Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing.

Publication ,  Journal Article
Cheon, SS; Wei, Q; Gurung, A; Youn, A; Bright, T; Poon, R; Whetstone, H; Guha, A; Alman, BA
Published in: FASEB J
April 2006

After cutaneous injury, a variety of cell types are activated to reconstitute the epithelial and dermal components of the skin. beta-Catenin plays disparate roles in keratinocytes and fibroblasts, inhibiting keratinocyte migration and activating fibroblast proliferation, suggesting that beta-catenin could either inhibit or enhance the healing process. How beta-catenin functions in concert with other signaling pathways important in the healing process is unknown. Wound size was examined in mice expressing conditional null or conditional stabilized alleles of beta-catenin, regulated by an adenovirus expressing cre-recombinase. The size of the wounds in the mice correlated with the protein level of beta-catenin. Using mice expressing these conditional alleles, we found that the wound phenotype imparted by Smad3 deficiency and by the injection of TGFbeta before wounding is mediated in part by beta-catenin. TGFbeta was not able to regulate proliferation in beta-catenin null fibroblasts, whereas keratinocyte proliferation rate was independent of beta-catenin. When mice are treated with lithium, beta-catenin-mediated signaling was activated in cutaneous wounds, which healed with a larger size. These results demonstrate a crucial role for beta-catenin in regulating cutaneous wound size. Furthermore, these data implicate mesenchymal cells as playing a critical role regulating wound size.

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Published In

FASEB J

DOI

EISSN

1530-6860

Publication Date

April 2006

Volume

20

Issue

6

Start / End Page

692 / 701

Location

United States

Related Subject Headings

  • beta Catenin
  • Wounds and Injuries
  • Wound Healing
  • Transforming Growth Factor beta
  • Skin
  • Signal Transduction
  • Recombinases
  • Mice, Transgenic
  • Mice, Knockout
  • Mice
 

Citation

APA
Chicago
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Cheon, S. S., Wei, Q., Gurung, A., Youn, A., Bright, T., Poon, R., … Alman, B. A. (2006). Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. FASEB J, 20(6), 692–701. https://doi.org/10.1096/fj.05-4759com
Cheon, Sophia S., Qingxia Wei, Ananta Gurung, Andrew Youn, Tamara Bright, Raymond Poon, Heather Whetstone, Abhijit Guha, and Benjamin A. Alman. “Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing.FASEB J 20, no. 6 (April 2006): 692–701. https://doi.org/10.1096/fj.05-4759com.
Cheon SS, Wei Q, Gurung A, Youn A, Bright T, Poon R, et al. Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. FASEB J. 2006 Apr;20(6):692–701.
Cheon, Sophia S., et al. “Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing.FASEB J, vol. 20, no. 6, Apr. 2006, pp. 692–701. Pubmed, doi:10.1096/fj.05-4759com.
Cheon SS, Wei Q, Gurung A, Youn A, Bright T, Poon R, Whetstone H, Guha A, Alman BA. Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. FASEB J. 2006 Apr;20(6):692–701.

Published In

FASEB J

DOI

EISSN

1530-6860

Publication Date

April 2006

Volume

20

Issue

6

Start / End Page

692 / 701

Location

United States

Related Subject Headings

  • beta Catenin
  • Wounds and Injuries
  • Wound Healing
  • Transforming Growth Factor beta
  • Skin
  • Signal Transduction
  • Recombinases
  • Mice, Transgenic
  • Mice, Knockout
  • Mice