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Aggressive fibromatosis (desmoid tumor) is a monoclonal disorder.

Publication ,  Journal Article
Alman, BA; Pajerski, ME; Diaz-Cano, S; Corboy, K; Wolfe, HJ
Published in: Diagn Mol Pathol
April 1997

Aggressive fibromatosis (also called deep fibromatosis or desmoid tumor) is a proliferation of cytologically benign-appearing fibrocytes, often resulting in significant functional loss. The nature of the lesion is controversial: some evidence suggests that it is a reactive process, whereas other evidence supports a neoplastic etiology. The pattern of X chromosome inactivation, using a technique based on polymerase chain reaction (PCR) amplification of a hypervariable CAG repeat region flanking Hhal restriction sites of the human androgen receptor gene, was determined in four cases in which cryopreserved tumor and adjacent normal tissue were available. All four tumors demonstrated a monoclonal pattern, while the adjacent normal tissues demonstrated a polyclonal pattern. This demonstrates that aggressive fibromatosis is proliferation of cells derived from a single clone with a growth advantage, and thus is likely a neoplastic process.

Duke Scholars

Published In

Diagn Mol Pathol

DOI

ISSN

1052-9551

Publication Date

April 1997

Volume

6

Issue

2

Start / End Page

98 / 101

Location

United States

Related Subject Headings

  • X Chromosome
  • Soft Tissue Neoplasms
  • Sex Chromosome Aberrations
  • Receptors, Androgen
  • Polymerase Chain Reaction
  • Pathology
  • Leg
  • Humans
  • Fibromatosis, Aggressive
  • Female
 

Citation

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Chicago
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MLA
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Alman, B. A., Pajerski, M. E., Diaz-Cano, S., Corboy, K., & Wolfe, H. J. (1997). Aggressive fibromatosis (desmoid tumor) is a monoclonal disorder. Diagn Mol Pathol, 6(2), 98–101. https://doi.org/10.1097/00019606-199704000-00005
Alman, B. A., M. E. Pajerski, S. Diaz-Cano, K. Corboy, and H. J. Wolfe. “Aggressive fibromatosis (desmoid tumor) is a monoclonal disorder.Diagn Mol Pathol 6, no. 2 (April 1997): 98–101. https://doi.org/10.1097/00019606-199704000-00005.
Alman BA, Pajerski ME, Diaz-Cano S, Corboy K, Wolfe HJ. Aggressive fibromatosis (desmoid tumor) is a monoclonal disorder. Diagn Mol Pathol. 1997 Apr;6(2):98–101.
Alman, B. A., et al. “Aggressive fibromatosis (desmoid tumor) is a monoclonal disorder.Diagn Mol Pathol, vol. 6, no. 2, Apr. 1997, pp. 98–101. Pubmed, doi:10.1097/00019606-199704000-00005.
Alman BA, Pajerski ME, Diaz-Cano S, Corboy K, Wolfe HJ. Aggressive fibromatosis (desmoid tumor) is a monoclonal disorder. Diagn Mol Pathol. 1997 Apr;6(2):98–101.

Published In

Diagn Mol Pathol

DOI

ISSN

1052-9551

Publication Date

April 1997

Volume

6

Issue

2

Start / End Page

98 / 101

Location

United States

Related Subject Headings

  • X Chromosome
  • Soft Tissue Neoplasms
  • Sex Chromosome Aberrations
  • Receptors, Androgen
  • Polymerase Chain Reaction
  • Pathology
  • Leg
  • Humans
  • Fibromatosis, Aggressive
  • Female