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Aggressive fibromatosis.

Publication ,  Journal Article
Alman, BA; Goldberg, MJ; Naber, SP; Galanopoulous, T; Antoniades, HN; Wolfe, HJ
Published in: J Pediatr Orthop
January 1992

Ten patients with aggressive fibromatosis of the extremities were prospectively followed for 2-6 years. Results of treatment methods were compared. Five patients underwent three-dimensional imaging with and without intravenous contrast, and the images were compared with the anatomic extent of the resected lesion. Pathologic specimens and control tissue were tested for the presence of estrogen and progesterone receptors and for expression of the c-sis oncogene and platelet-derived growth factor (PDGF), potent mitogens for fibrocytes. Wider surgical resection resulted in a lower recurrence rate, but current chemotherapeutic agents were not effective in eradicating the tumors. Intravenous contrast enhanced the lesions. Two thirds of the tumors tested had estrogen or progesterone receptors. All tumors tested had inappropriate expression of c-sis and PDGF. This inappropriate expression may be responsible for the underlying pathobiology and deregulation of control of growth in aggressive fibromatosis.

Duke Scholars

Published In

J Pediatr Orthop

ISSN

0271-6798

Publication Date

January 1992

Volume

12

Issue

1

Start / End Page

1 / 10

Location

United States

Related Subject Headings

  • Soft Tissue Neoplasms
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Platelet-Derived Growth Factor
  • Orthopedics
  • Oncogenes
  • Male
  • Leg
  • Infant, Newborn
  • Humans
 

Citation

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ICMJE
MLA
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Alman, B. A., Goldberg, M. J., Naber, S. P., Galanopoulous, T., Antoniades, H. N., & Wolfe, H. J. (1992). Aggressive fibromatosis. J Pediatr Orthop, 12(1), 1–10.
Alman, B. A., M. J. Goldberg, S. P. Naber, T. Galanopoulous, H. N. Antoniades, and H. J. Wolfe. “Aggressive fibromatosis.J Pediatr Orthop 12, no. 1 (January 1992): 1–10.
Alman BA, Goldberg MJ, Naber SP, Galanopoulous T, Antoniades HN, Wolfe HJ. Aggressive fibromatosis. J Pediatr Orthop. 1992 Jan;12(1):1–10.
Alman, B. A., et al. “Aggressive fibromatosis.J Pediatr Orthop, vol. 12, no. 1, Jan. 1992, pp. 1–10.
Alman BA, Goldberg MJ, Naber SP, Galanopoulous T, Antoniades HN, Wolfe HJ. Aggressive fibromatosis. J Pediatr Orthop. 1992 Jan;12(1):1–10.

Published In

J Pediatr Orthop

ISSN

0271-6798

Publication Date

January 1992

Volume

12

Issue

1

Start / End Page

1 / 10

Location

United States

Related Subject Headings

  • Soft Tissue Neoplasms
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Platelet-Derived Growth Factor
  • Orthopedics
  • Oncogenes
  • Male
  • Leg
  • Infant, Newborn
  • Humans