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Morphological and biochemical properties of a new human breast cancer cell line.

Publication ,  Journal Article
Langlois, AJ; Holder, WD; Iglehart, JD; Nelson-Rees, WA; Wells, SA; Bolognesi, DP
Published in: Cancer Res
July 1979

DU4475 is a new human breast cell line derived from a cutaneous metastatic nodule from a patient with advanced breast cancer. It has been in continuous culture for more than 1 year and has survived 140 subcultivations. The cells grow in suspension, displaying clusters and free-floating aggregates with serpentine-like outgrowths. The cell line is hypotetraploid with modal chromosome numbers between 86 and 93 and possesses five to six distinctive marker chromosomes. The cells grow readily in athymic nude mice and produce tumors from which cells can be reintroduced to culture in vitro.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

July 1979

Volume

39

Issue

7 Pt 1

Start / End Page

2604 / 2613

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Receptors, Cell Surface
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Isoenzymes
  • Humans
  • Glucosephosphate Dehydrogenase
  • Female
  • Chromosomes
  • Cell Line
 

Citation

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MLA
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Langlois, A. J., Holder, W. D., Iglehart, J. D., Nelson-Rees, W. A., Wells, S. A., & Bolognesi, D. P. (1979). Morphological and biochemical properties of a new human breast cancer cell line. Cancer Res, 39(7 Pt 1), 2604–2613.
Langlois, A. J., W. D. Holder, J. D. Iglehart, W. A. Nelson-Rees, S. A. Wells, and D. P. Bolognesi. “Morphological and biochemical properties of a new human breast cancer cell line.Cancer Res 39, no. 7 Pt 1 (July 1979): 2604–13.
Langlois AJ, Holder WD, Iglehart JD, Nelson-Rees WA, Wells SA, Bolognesi DP. Morphological and biochemical properties of a new human breast cancer cell line. Cancer Res. 1979 Jul;39(7 Pt 1):2604–13.
Langlois, A. J., et al. “Morphological and biochemical properties of a new human breast cancer cell line.Cancer Res, vol. 39, no. 7 Pt 1, July 1979, pp. 2604–13.
Langlois AJ, Holder WD, Iglehart JD, Nelson-Rees WA, Wells SA, Bolognesi DP. Morphological and biochemical properties of a new human breast cancer cell line. Cancer Res. 1979 Jul;39(7 Pt 1):2604–2613.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

July 1979

Volume

39

Issue

7 Pt 1

Start / End Page

2604 / 2613

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Receptors, Cell Surface
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Isoenzymes
  • Humans
  • Glucosephosphate Dehydrogenase
  • Female
  • Chromosomes
  • Cell Line