Skip to main content
Journal cover image

Future directions in toxicity prevention.

Publication ,  Conference
Brizel, DM
Published in: Seminars in radiation oncology
October 1998

The modern practice of radiation therapy has developed over several decades, taking into consideration the anatomic location of the tumor, technical aspects of radiation delivery, combined treatment modalities, and patient comorbidity. Improved understanding of tumor biology and kinetics has resulted in a more intensive application of multimodality therapy for many forms of cancer in the endeavor to increase treatment efficacy. However, increased treatment intensity carries a risk of increased toxicity. Conversely, reduction of toxicity by lessening treatment intensity incurs the risk of reduced efficacy. Preventing or minimizing toxicity while maintaining or increasing efficacy is necessary for overall improvement in the therapeutic ratio. New methods for reducing toxicity are currently being explored and include identification of risk factors associated with increased toxicity, the development of radioprotectants, and the use of growth factors to accelerate the replacement of damaged cells.

Duke Scholars

Published In

Seminars in radiation oncology

EISSN

1532-9461

ISSN

1053-4296

Publication Date

October 1998

Volume

8

Issue

4 Suppl 1

Start / End Page

17 / 20

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Radiotherapy Dosage
  • Radiotherapy
  • Radiation-Protective Agents
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Growth Substances
  • Forecasting
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Brizel, D. M. (1998). Future directions in toxicity prevention. In Seminars in radiation oncology (Vol. 8, pp. 17–20).
Brizel, D. M. “Future directions in toxicity prevention.” In Seminars in Radiation Oncology, 8:17–20, 1998.
Brizel DM. Future directions in toxicity prevention. In: Seminars in radiation oncology. 1998. p. 17–20.
Brizel, D. M. “Future directions in toxicity prevention.Seminars in Radiation Oncology, vol. 8, no. 4 Suppl 1, 1998, pp. 17–20.
Brizel DM. Future directions in toxicity prevention. Seminars in radiation oncology. 1998. p. 17–20.
Journal cover image

Published In

Seminars in radiation oncology

EISSN

1532-9461

ISSN

1053-4296

Publication Date

October 1998

Volume

8

Issue

4 Suppl 1

Start / End Page

17 / 20

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Radiotherapy Dosage
  • Radiotherapy
  • Radiation-Protective Agents
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Growth Substances
  • Forecasting