Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Cigarette smoking status has a modifying effect on the association between polymorphisms in KALRN and measures of cardiovascular risk in the diabetes heart study

Publication ,  Journal Article
Rudock, ME; Cox, AJ; Ziegler, JT; Lehtinen, AB; Connelly, JJ; Freedman, BI; Carr, JJ; Langefeld, CD; Hauser, ER; Horne, BD; Bowden, DW
Published in: Genes and Genomics
October 1, 2011

All manifestations of cardiovascular disease (CVD) are substantially more common in patients with type 2 diabetes mellitus (T2DM) than in non-diabeticindividuals. The current study evaluated KALRN, a gene previously linked to CVD, as a contributor to CVD in a sample enriched for T2DM. Specifically, the potential modifying effectof cigarette smoking was examined. A total of 28 SNPs in KALRNwere genotyped in 1001 European Americans from 369 Diabetes Heart Study (DHS) families, as well as 762 population-based controls. The association between each SNP and both qualitative and quantitative CVD disease phenotypes was determined using generalized estimating equations and variance component models, respectively. Selected KALRNSNPs were found to be associated with both the qualitative (T2DM, CVD, metabolic syndrome) and quantitative traits (C-reactive protein and abdominal aortic calcified plaque). Interaction analysis and stratification were then used to test whether smoking modulates the genetic effects of KALRN. The strongest evidence of a modifying effect of smoking status was observed for rs9289231 and intima-media thickness (p=9.0x10−4) and abdominal aortic calcified plaque (p=3.0x10−4). Overall, following stratification by smoking status, the evidence of association with quantitative traits was more pronounced in smokers compared to non-smokers. The strongest association for smokers was between rs1720960 and abdominal aortic calcified plaque (p=2.6x10 −5), while in non-smokers there was no observed association. KALRNvariants are associated with measures of CVD and T2DM in the DHS sample with smoking status observed to have a significant modifying effect on these associations.

Duke Scholars

Published In

Genes and Genomics

DOI

EISSN

2092-9293

ISSN

1976-9571

Publication Date

October 1, 2011

Volume

33

Issue

5

Start / End Page

483 / 490

Related Subject Headings

  • 3105 Genetics
  • 0604 Genetics
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rudock, M. E., Cox, A. J., Ziegler, J. T., Lehtinen, A. B., Connelly, J. J., Freedman, B. I., … Bowden, D. W. (2011). Cigarette smoking status has a modifying effect on the association between polymorphisms in KALRN and measures of cardiovascular risk in the diabetes heart study. Genes and Genomics, 33(5), 483–490. https://doi.org/10.1007/s13258-011-0069-2
Rudock, M. E., A. J. Cox, J. T. Ziegler, A. B. Lehtinen, J. J. Connelly, B. I. Freedman, J. J. Carr, et al. “Cigarette smoking status has a modifying effect on the association between polymorphisms in KALRN and measures of cardiovascular risk in the diabetes heart study.” Genes and Genomics 33, no. 5 (October 1, 2011): 483–90. https://doi.org/10.1007/s13258-011-0069-2.
Rudock ME, Cox AJ, Ziegler JT, Lehtinen AB, Connelly JJ, Freedman BI, et al. Cigarette smoking status has a modifying effect on the association between polymorphisms in KALRN and measures of cardiovascular risk in the diabetes heart study. Genes and Genomics. 2011 Oct 1;33(5):483–90.
Rudock, M. E., et al. “Cigarette smoking status has a modifying effect on the association between polymorphisms in KALRN and measures of cardiovascular risk in the diabetes heart study.” Genes and Genomics, vol. 33, no. 5, Oct. 2011, pp. 483–90. Scopus, doi:10.1007/s13258-011-0069-2.
Rudock ME, Cox AJ, Ziegler JT, Lehtinen AB, Connelly JJ, Freedman BI, Carr JJ, Langefeld CD, Hauser ER, Horne BD, Bowden DW. Cigarette smoking status has a modifying effect on the association between polymorphisms in KALRN and measures of cardiovascular risk in the diabetes heart study. Genes and Genomics. 2011 Oct 1;33(5):483–490.
Journal cover image

Published In

Genes and Genomics

DOI

EISSN

2092-9293

ISSN

1976-9571

Publication Date

October 1, 2011

Volume

33

Issue

5

Start / End Page

483 / 490

Related Subject Headings

  • 3105 Genetics
  • 0604 Genetics
  • 0601 Biochemistry and Cell Biology