Association between the 7 S RNA and the lupus La protein varies among cell types.
The La antigen recognized by certain lupus erythematosus autoantibodies was found to be predominantly associated with 7 S RNA in baby hamster kidney cells and human Raji cells, but not in HeLa cells where mainly the 7-2 RNA was associated with the La protein. In mouse myeloma cells (MPC-11) and mouse lymphoma cells (WEHI) that secrete immunoglobulins, equal amounts of 7 S and 7-2 RNAs were present in anti-La immunoprecipitates. The highly conserved 7 S RNA is a component of the signal recognition particle involved in protein secretion (Walter, P., and Blobel, G. (1982) Nature (Lond.) 299, 691-698), and its association with the La antigen appeared to be cell-type specific. Thus, it is possible that the La-7 S RNA association correlates with the abundance of 7 S RNA or with the secretory activity of the cell type.
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Related Subject Headings
- SS-B Antigen
- Ribonucleoproteins
- RNA
- Molecular Weight
- Mice
- Lupus Erythematosus, Systemic
- Humans
- Cricetinae
- Cells, Cultured
- Cell Line
Citation
Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- SS-B Antigen
- Ribonucleoproteins
- RNA
- Molecular Weight
- Mice
- Lupus Erythematosus, Systemic
- Humans
- Cricetinae
- Cells, Cultured
- Cell Line