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Association between the 7 S RNA and the lupus La protein varies among cell types.

Publication ,  Journal Article
Chambers, JC; Kurilla, MG; Keene, JD
Published in: J Biol Chem
October 10, 1983

The La antigen recognized by certain lupus erythematosus autoantibodies was found to be predominantly associated with 7 S RNA in baby hamster kidney cells and human Raji cells, but not in HeLa cells where mainly the 7-2 RNA was associated with the La protein. In mouse myeloma cells (MPC-11) and mouse lymphoma cells (WEHI) that secrete immunoglobulins, equal amounts of 7 S and 7-2 RNAs were present in anti-La immunoprecipitates. The highly conserved 7 S RNA is a component of the signal recognition particle involved in protein secretion (Walter, P., and Blobel, G. (1982) Nature (Lond.) 299, 691-698), and its association with the La antigen appeared to be cell-type specific. Thus, it is possible that the La-7 S RNA association correlates with the abundance of 7 S RNA or with the secretory activity of the cell type.

Duke Scholars

Published In

J Biol Chem

ISSN

0021-9258

Publication Date

October 10, 1983

Volume

258

Issue

19

Start / End Page

11438 / 11441

Location

United States

Related Subject Headings

  • SS-B Antigen
  • Ribonucleoproteins
  • RNA
  • Molecular Weight
  • Mice
  • Lupus Erythematosus, Systemic
  • Humans
  • Cricetinae
  • Cells, Cultured
  • Cell Line
 

Citation

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MLA
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Chambers, J. C., Kurilla, M. G., & Keene, J. D. (1983). Association between the 7 S RNA and the lupus La protein varies among cell types. J Biol Chem, 258(19), 11438–11441.
Chambers, J. C., M. G. Kurilla, and J. D. Keene. “Association between the 7 S RNA and the lupus La protein varies among cell types.J Biol Chem 258, no. 19 (October 10, 1983): 11438–41.
Chambers JC, Kurilla MG, Keene JD. Association between the 7 S RNA and the lupus La protein varies among cell types. J Biol Chem. 1983 Oct 10;258(19):11438–41.
Chambers, J. C., et al. “Association between the 7 S RNA and the lupus La protein varies among cell types.J Biol Chem, vol. 258, no. 19, Oct. 1983, pp. 11438–41.
Chambers JC, Kurilla MG, Keene JD. Association between the 7 S RNA and the lupus La protein varies among cell types. J Biol Chem. 1983 Oct 10;258(19):11438–11441.

Published In

J Biol Chem

ISSN

0021-9258

Publication Date

October 10, 1983

Volume

258

Issue

19

Start / End Page

11438 / 11441

Location

United States

Related Subject Headings

  • SS-B Antigen
  • Ribonucleoproteins
  • RNA
  • Molecular Weight
  • Mice
  • Lupus Erythematosus, Systemic
  • Humans
  • Cricetinae
  • Cells, Cultured
  • Cell Line