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Quantitative dynamic contrast-enhanced MRI of pelvic and lumbar bone marrow: effect of age and marrow fat content on pharmacokinetic parameter values.

Publication ,  Journal Article
Breault, SR; Heye, T; Bashir, MR; Dale, BM; Merkle, EM; Reiner, CS; Faridi, KF; Gupta, RT
Published in: AJR Am J Roentgenol
March 2013

OBJECTIVE: The purpose of this study was to determine the effects of age and fat content on quantitative dynamic contrast-enhanced MRI (DCE-MRI) parameters in the bone marrow of the lumbar spine and pelvis. The interreader reproducibility of this technique will also be assessed. MATERIALS AND METHODS: Forty-three DCE-MRI studies of the female pelvis defined the study group. Quantitative pharmacokinetic perfusion parameters of lumbar and pelvic marrow were analyzed by three readers on a DCE-MRI postprocessing platform. Linear regression analysis was performed to determine the effect of age and marrow fat fraction on the parameters of transfer constant (K(trans)), efflux rate constant (K(ep)), extravascular extracellular space (V(e)), and initial area under the gadolinium curve at 60 seconds (iAUGC(60)). Interreader agreement was assessed by means of intraclass correlation coefficient calculation. RESULTS: A weak but statistically significant correlation was established between both age and fat fraction and the parameters K(trans) (R(2) = 0.14) and K(ep) (R(2) = 0.09). There was also a weak but statistically significant correlation between fat fraction and V(e) (R(2) = 0.116) and iAUGC(60) (R(2) = 0.108), but no correlation between age and these parameters. Intraclass correlation coefficients of parameter measurements by different readers were all greater than 0.7 at the p < 0.05 level. CONCLUSION: Age and fat fraction have small measurable effects on quantitative DCE-MRI parameters in bone marrow. However, given the wide interindividual variation of these parameters, these effects are unlikely to confound changes related to malignancy or treatment. Also of note, there was strong interreader reproducibility of parameter measurements among a range of experience levels, suggesting that the reader-reader experience level may not represent a significant source of variability in bone marrow DCE-MRI.

Duke Scholars

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

March 2013

Volume

200

Issue

3

Start / End Page

W297 / W303

Location

United States

Related Subject Headings

  • Young Adult
  • Tissue Distribution
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Pelvic Bones
  • Organometallic Compounds
  • Organ Specificity
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Metabolic Clearance Rate
 

Citation

APA
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ICMJE
MLA
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Breault, S. R., Heye, T., Bashir, M. R., Dale, B. M., Merkle, E. M., Reiner, C. S., … Gupta, R. T. (2013). Quantitative dynamic contrast-enhanced MRI of pelvic and lumbar bone marrow: effect of age and marrow fat content on pharmacokinetic parameter values. AJR Am J Roentgenol, 200(3), W297–W303. https://doi.org/10.2214/AJR.12.9080
Breault, Steven R., Tobias Heye, Mustafa R. Bashir, Brian M. Dale, Elmar M. Merkle, Caecilia S. Reiner, Kamil F. Faridi, and Rajan T. Gupta. “Quantitative dynamic contrast-enhanced MRI of pelvic and lumbar bone marrow: effect of age and marrow fat content on pharmacokinetic parameter values.AJR Am J Roentgenol 200, no. 3 (March 2013): W297–303. https://doi.org/10.2214/AJR.12.9080.
Breault SR, Heye T, Bashir MR, Dale BM, Merkle EM, Reiner CS, et al. Quantitative dynamic contrast-enhanced MRI of pelvic and lumbar bone marrow: effect of age and marrow fat content on pharmacokinetic parameter values. AJR Am J Roentgenol. 2013 Mar;200(3):W297–303.
Breault, Steven R., et al. “Quantitative dynamic contrast-enhanced MRI of pelvic and lumbar bone marrow: effect of age and marrow fat content on pharmacokinetic parameter values.AJR Am J Roentgenol, vol. 200, no. 3, Mar. 2013, pp. W297–303. Pubmed, doi:10.2214/AJR.12.9080.
Breault SR, Heye T, Bashir MR, Dale BM, Merkle EM, Reiner CS, Faridi KF, Gupta RT. Quantitative dynamic contrast-enhanced MRI of pelvic and lumbar bone marrow: effect of age and marrow fat content on pharmacokinetic parameter values. AJR Am J Roentgenol. 2013 Mar;200(3):W297–W303.

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

March 2013

Volume

200

Issue

3

Start / End Page

W297 / W303

Location

United States

Related Subject Headings

  • Young Adult
  • Tissue Distribution
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Pelvic Bones
  • Organometallic Compounds
  • Organ Specificity
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Metabolic Clearance Rate