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The association of opioid use with incident lower extremity fractures in spinal cord injury.

Publication ,  Journal Article
Carbone, LD; Chin, AS; Lee, TA; Burns, SP; Svircev, JN; Hoenig, HM; Akhigbe, T; Weaver, FM
Published in: J Spinal Cord Med
March 2013

OBJECTIVE: To determine the association between opioid use and lower extremity fracture risk in men with spinal cord injury (SCI). DESIGN: Retrospective cohort study. SETTING: Veterans Affairs Healthcare System. PARTICIPANTS: In total, 7447 male Veterans with a history of a traumatic SCI identified from the Veterans Affairs (VA) Spinal Cord Dysfunction Registry (SCD) from September 2002 through October 2007 and followed through October 2010. OUTCOME MEASURES: Incident lower extremity fractures by use of opioids. RESULTS: In individuals identified from the VA SCD Registry 2002-2007, opioid use was quite common, with approximately 70% of the cohort having received a prescription for an opioid. Overall, there were 892 incident lower extremity fractures over the time period of this study (597 fractures in the opioid users and 295 fractures in the non-opioid users). After adjusting for covariates, there was a statistically significant relationship between opioid use and increased risk for lower extremity fractures (hazard ratio 1.82 (95% confidence interval 1.59-2.09)). Shorter duration of use (<6 months) and higher doses were positively related to fracture risk (P < 0.0001). CONCLUSIONS: Opioid use is quite common in SCI and is associated with an increased risk for lower extremity fractures. Careful attention to fracture prevention is warranted in patients with SCI, particularly upon initiation of an opioid prescription and when higher doses are used.

Duke Scholars

Published In

J Spinal Cord Med

DOI

ISSN

1079-0268

Publication Date

March 2013

Volume

36

Issue

2

Start / End Page

91 / 96

Location

England

Related Subject Headings

  • Veterans
  • Spinal Cord Injuries
  • Retrospective Studies
  • Rehabilitation
  • Pain
  • Male
  • Lower Extremity
  • Humans
  • Fractures, Bone
  • Cohort Studies
 

Citation

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ICMJE
MLA
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Carbone, L. D., Chin, A. S., Lee, T. A., Burns, S. P., Svircev, J. N., Hoenig, H. M., … Weaver, F. M. (2013). The association of opioid use with incident lower extremity fractures in spinal cord injury. J Spinal Cord Med, 36(2), 91–96. https://doi.org/10.1179/2045772312Y.0000000060
Carbone, Laura D., Amy S. Chin, Todd A. Lee, Stephen P. Burns, Jelena N. Svircev, Helen M. Hoenig, Titilola Akhigbe, and Frances M. Weaver. “The association of opioid use with incident lower extremity fractures in spinal cord injury.J Spinal Cord Med 36, no. 2 (March 2013): 91–96. https://doi.org/10.1179/2045772312Y.0000000060.
Carbone LD, Chin AS, Lee TA, Burns SP, Svircev JN, Hoenig HM, et al. The association of opioid use with incident lower extremity fractures in spinal cord injury. J Spinal Cord Med. 2013 Mar;36(2):91–6.
Carbone, Laura D., et al. “The association of opioid use with incident lower extremity fractures in spinal cord injury.J Spinal Cord Med, vol. 36, no. 2, Mar. 2013, pp. 91–96. Pubmed, doi:10.1179/2045772312Y.0000000060.
Carbone LD, Chin AS, Lee TA, Burns SP, Svircev JN, Hoenig HM, Akhigbe T, Weaver FM. The association of opioid use with incident lower extremity fractures in spinal cord injury. J Spinal Cord Med. 2013 Mar;36(2):91–96.
Journal cover image

Published In

J Spinal Cord Med

DOI

ISSN

1079-0268

Publication Date

March 2013

Volume

36

Issue

2

Start / End Page

91 / 96

Location

England

Related Subject Headings

  • Veterans
  • Spinal Cord Injuries
  • Retrospective Studies
  • Rehabilitation
  • Pain
  • Male
  • Lower Extremity
  • Humans
  • Fractures, Bone
  • Cohort Studies