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Androgens promote prostate cancer cell growth through induction of autophagy.

Publication ,  Journal Article
Shi, Y; Han, JJ; Tennakoon, JB; Mehta, FF; Merchant, FA; Burns, AR; Howe, MK; McDonnell, DP; Frigo, DE
Published in: Mol Endocrinol
February 2013

Androgens regulate both the physiological development of the prostate and the pathology of prostatic diseases. However, the mechanisms by which androgens exert their regulatory activities on these processes are poorly understood. In this study, we have determined that androgens regulate overall cell metabolism and cell growth, in part, by increasing autophagy in prostate cancer cells. Importantly, inhibition of autophagy using either pharmacological or molecular inhibitors significantly abrogated androgen-induced prostate cancer cell growth. Mechanistically, androgen-mediated autophagy appears to promote cell growth by augmenting intracellular lipid accumulation, an effect previously demonstrated to be necessary for prostate cancer cell growth. Further, autophagy and subsequent cell growth is potentiated, in part, by androgen-mediated increases in reactive oxygen species. These findings demonstrate a role for increased fat metabolism and autophagy in prostatic neoplasias and highlight the potential of targeting underexplored metabolic pathways for the development of novel therapeutics.

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Published In

Mol Endocrinol

DOI

EISSN

1944-9917

Publication Date

February 2013

Volume

27

Issue

2

Start / End Page

280 / 295

Location

United States

Related Subject Headings

  • Reactive Oxygen Species
  • RNA, Small Interfering
  • RNA Interference
  • Prostatic Neoplasms
  • Male
  • Lipogenesis
  • Lipids
  • Lipid Metabolism
  • Humans
  • Endocrinology & Metabolism
 

Citation

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Shi, Y., Han, J. J., Tennakoon, J. B., Mehta, F. F., Merchant, F. A., Burns, A. R., … Frigo, D. E. (2013). Androgens promote prostate cancer cell growth through induction of autophagy. Mol Endocrinol, 27(2), 280–295. https://doi.org/10.1210/me.2012-1260
Shi, Yan, Jenny J. Han, Jayantha B. Tennakoon, Fabiola F. Mehta, Fatima A. Merchant, Alan R. Burns, Matthew K. Howe, Donald P. McDonnell, and Daniel E. Frigo. “Androgens promote prostate cancer cell growth through induction of autophagy.Mol Endocrinol 27, no. 2 (February 2013): 280–95. https://doi.org/10.1210/me.2012-1260.
Shi Y, Han JJ, Tennakoon JB, Mehta FF, Merchant FA, Burns AR, et al. Androgens promote prostate cancer cell growth through induction of autophagy. Mol Endocrinol. 2013 Feb;27(2):280–95.
Shi, Yan, et al. “Androgens promote prostate cancer cell growth through induction of autophagy.Mol Endocrinol, vol. 27, no. 2, Feb. 2013, pp. 280–95. Pubmed, doi:10.1210/me.2012-1260.
Shi Y, Han JJ, Tennakoon JB, Mehta FF, Merchant FA, Burns AR, Howe MK, McDonnell DP, Frigo DE. Androgens promote prostate cancer cell growth through induction of autophagy. Mol Endocrinol. 2013 Feb;27(2):280–295.

Published In

Mol Endocrinol

DOI

EISSN

1944-9917

Publication Date

February 2013

Volume

27

Issue

2

Start / End Page

280 / 295

Location

United States

Related Subject Headings

  • Reactive Oxygen Species
  • RNA, Small Interfering
  • RNA Interference
  • Prostatic Neoplasms
  • Male
  • Lipogenesis
  • Lipids
  • Lipid Metabolism
  • Humans
  • Endocrinology & Metabolism