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Molecular markers of therapeutic resistance in breast cancer.

Publication ,  Journal Article
Zhou, L; Luo, Y; Li, K; Tian, L; Wang, M; Li, C; Huang, Q
Published in: Hum Pathol
July 2013

Resistance to chemotherapy and endocrine therapy is a serious obstacle in the treatment of breast cancer. Highly specific biomarkers for predicting therapeutic resistance have not yet been identified. In this study, the amounts of aldehyde dehydrogenase 1, cleaved caspase 3, cyclooxygenase 2, phosphorylated Akt, Ki-67, and H2AX proteins were measured by immunohistochemical staining in 113 breast cancer tissues, and their predictive ability for therapeutic resistance was investigated. The patients were receiving chemotherapy (n = 30), endocrine therapy (n = 22), or combined chemotherapy and endocrine therapy (n = 61). Expression of aldehyde dehydrogenase 1, cleaved caspase 3, and cyclooxygenase 2 correlated significantly with a higher relapse rate (P < .05 or P < .01) and shorter survival (P < .01 or P < .001) in triple-negative patients receiving chemotherapy. In addition, cyclooxygenase 2 expression was an independent predictor of a poor prognosis (P < .05). On the other hand, aldehyde dehydrogenase 1 expression correlated significantly with shorter survival in patients receiving combined therapy (P < .01) but showed no association with relapse. No correlation was observed between Ki-67, phosphorylated Akt, and H2AX expression and survival or relapse in any group of patients. These data suggest that aldehyde dehydrogenase 1, cleaved caspase 3, and cyclooxygenase 2 are useful markers for therapeutic resistance in breast cancer.

Duke Scholars

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Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

July 2013

Volume

44

Issue

7

Start / End Page

1421 / 1428

Location

United States

Related Subject Headings

  • Survival Rate
  • Retinal Dehydrogenase
  • Pathology
  • Neoplasm Staging
  • Middle Aged
  • Isoenzymes
  • Humans
  • Female
  • Drug Resistance, Neoplasm
  • China
 

Citation

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Zhou, L., Luo, Y., Li, K., Tian, L., Wang, M., Li, C., & Huang, Q. (2013). Molecular markers of therapeutic resistance in breast cancer. Hum Pathol, 44(7), 1421–1428. https://doi.org/10.1016/j.humpath.2012.10.027
Zhou, Ling, Yanli Luo, Ke Li, Ling Tian, Min Wang, Chuanyuan Li, and Qian Huang. “Molecular markers of therapeutic resistance in breast cancer.Hum Pathol 44, no. 7 (July 2013): 1421–28. https://doi.org/10.1016/j.humpath.2012.10.027.
Zhou L, Luo Y, Li K, Tian L, Wang M, Li C, et al. Molecular markers of therapeutic resistance in breast cancer. Hum Pathol. 2013 Jul;44(7):1421–8.
Zhou, Ling, et al. “Molecular markers of therapeutic resistance in breast cancer.Hum Pathol, vol. 44, no. 7, July 2013, pp. 1421–28. Pubmed, doi:10.1016/j.humpath.2012.10.027.
Zhou L, Luo Y, Li K, Tian L, Wang M, Li C, Huang Q. Molecular markers of therapeutic resistance in breast cancer. Hum Pathol. 2013 Jul;44(7):1421–1428.
Journal cover image

Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

July 2013

Volume

44

Issue

7

Start / End Page

1421 / 1428

Location

United States

Related Subject Headings

  • Survival Rate
  • Retinal Dehydrogenase
  • Pathology
  • Neoplasm Staging
  • Middle Aged
  • Isoenzymes
  • Humans
  • Female
  • Drug Resistance, Neoplasm
  • China