Skip to main content
Journal cover image

MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction.

Publication ,  Journal Article
Tan, PB; Lackner, MR; Kim, SK
Published in: Cell
May 15, 1998

The let-23 receptor/mpk-1 MAP kinase signaling pathway induces the vulva in C. elegans. We show that MPK-1 directly regulates both the LIN-31 winged-helix and the LIN-1 Ets transcription factors to specify the vulval cell fate. lin-31 and lin-1 act genetically downstream of mpk-1, and both proteins can be directly phosphorylated by MAP kinase. LIN-31 binds to LIN-1, and the LIN-1/LIN-31 complex inhibits vulval induction. Phosphorylation of LIN-31 by MPK-1 disrupts the LIN-1/LIN-31 complex, relieving vulval inhibition. Phosphorylated LIN-31 may also act as a transcriptional activator, promoting vulval cell fates. LIN-31 is a vulval-specific effector of MPK-1, while LIN-1 acts as a general effector. The partnership of tissue-specific and general effectors may confer specificity onto commonly used signaling pathways, creating distinct tissue-specific outcomes.

Duke Scholars

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

May 15, 1998

Volume

93

Issue

4

Start / End Page

569 / 580

Location

United States

Related Subject Headings

  • Vulva
  • Transgenes
  • Transcription Factors
  • Stem Cells
  • Signal Transduction
  • Recombinant Fusion Proteins
  • Protein Serine-Threonine Kinases
  • Phosphorylation
  • Organ Specificity
  • Mutation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tan, P. B., Lackner, M. R., & Kim, S. K. (1998). MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction. Cell, 93(4), 569–580. https://doi.org/10.1016/s0092-8674(00)81186-1
Tan, P. B., M. R. Lackner, and S. K. Kim. “MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction.Cell 93, no. 4 (May 15, 1998): 569–80. https://doi.org/10.1016/s0092-8674(00)81186-1.
Tan, P. B., et al. “MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction.Cell, vol. 93, no. 4, May 1998, pp. 569–80. Pubmed, doi:10.1016/s0092-8674(00)81186-1.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

May 15, 1998

Volume

93

Issue

4

Start / End Page

569 / 580

Location

United States

Related Subject Headings

  • Vulva
  • Transgenes
  • Transcription Factors
  • Stem Cells
  • Signal Transduction
  • Recombinant Fusion Proteins
  • Protein Serine-Threonine Kinases
  • Phosphorylation
  • Organ Specificity
  • Mutation