Effects of Y27632 on keratinocyte procurement and wound healing.
Publication
, Journal Article
Gandham, VD; Maddala, RL; Rao, V; Jin, JY; Epstein, DL; Hall, RP; Zhang, JY
Published in: Clin Exp Dermatol
October 2013
A number of Rho-kinase inhibitors have been developed for various clinical applications. We examined the effects of the Rho-kinase inhibitor Y27632 on keratinocyte proliferation and migration, and found that it promoted primary human keratinocyte proliferation and migration in both monolayer and skin explant cultures. In addition, topical application of Y27632 enhanced cutaneous wound closure in the majority of wounds in mice. The growth and migration effects of Y27632 appeared to be specific to keratinocytes compared with dermal fibroblasts, and required intact Jun kinase function. Y27632 seems to be a promising agent for keratinocyte procurement and wounding healing.
Duke Scholars
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Published In
Clin Exp Dermatol
DOI
EISSN
1365-2230
Publication Date
October 2013
Volume
38
Issue
7
Start / End Page
782 / 786
Location
England
Related Subject Headings
- rho-Associated Kinases
- Wound Healing
- Pyridines
- Mice
- Keratinocytes
- Humans
- Enzyme Inhibitors
- Disease Models, Animal
- Dermatology & Venereal Diseases
- Cells, Cultured
Citation
APA
Chicago
ICMJE
MLA
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Gandham, V. D., Maddala, R. L., Rao, V., Jin, J. Y., Epstein, D. L., Hall, R. P., & Zhang, J. Y. (2013). Effects of Y27632 on keratinocyte procurement and wound healing. Clin Exp Dermatol, 38(7), 782–786. https://doi.org/10.1111/ced.12067
Gandham, V. D., R. L. Maddala, V. Rao, J. Y. Jin, D. L. Epstein, R. P. Hall, and J. Y. Zhang. “Effects of Y27632 on keratinocyte procurement and wound healing.” Clin Exp Dermatol 38, no. 7 (October 2013): 782–86. https://doi.org/10.1111/ced.12067.
Gandham VD, Maddala RL, Rao V, Jin JY, Epstein DL, Hall RP, et al. Effects of Y27632 on keratinocyte procurement and wound healing. Clin Exp Dermatol. 2013 Oct;38(7):782–6.
Gandham, V. D., et al. “Effects of Y27632 on keratinocyte procurement and wound healing.” Clin Exp Dermatol, vol. 38, no. 7, Oct. 2013, pp. 782–86. Pubmed, doi:10.1111/ced.12067.
Gandham VD, Maddala RL, Rao V, Jin JY, Epstein DL, Hall RP, Zhang JY. Effects of Y27632 on keratinocyte procurement and wound healing. Clin Exp Dermatol. 2013 Oct;38(7):782–786.
Published In
Clin Exp Dermatol
DOI
EISSN
1365-2230
Publication Date
October 2013
Volume
38
Issue
7
Start / End Page
782 / 786
Location
England
Related Subject Headings
- rho-Associated Kinases
- Wound Healing
- Pyridines
- Mice
- Keratinocytes
- Humans
- Enzyme Inhibitors
- Disease Models, Animal
- Dermatology & Venereal Diseases
- Cells, Cultured