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The role of microparticles in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus.

Publication ,  Journal Article
Dye, JR; Ullal, AJ; Pisetsky, DS
Published in: Scand J Immunol
August 2013

Microparticles (MPs) are small membrane-bound vesicles with potent biological activities that can promote the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus (SLE). These particles contain diverse cellular components and are shed from cells during apoptosis or activation. MPs can drive inflammation and autoimmunity by multiple mechanisms reflecting their content of bioactive molecules and ability to engage multiple receptor systems simultaneously. In the rheumatoid joint, particles can stimulate synovitis via their display of cytokines, chemokines, complement and angiogenesis factors. In SLE, particles can serve as an important source of extracellular nuclear molecules to signal 'danger' and form pathogenic immune complexes. Future studies will define the pathways by which particles promote pathogenesis, strategies to block their activity and their utility as biomarkers to assess disease activity and the response to therapy.

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Published In

Scand J Immunol

DOI

EISSN

1365-3083

Publication Date

August 2013

Volume

78

Issue

2

Start / End Page

140 / 148

Location

England

Related Subject Headings

  • Signal Transduction
  • Neovascularization, Pathologic
  • Lupus Erythematosus, Systemic
  • Joints
  • Immunology
  • Immunologic Factors
  • Humans
  • Cytokines
  • Complement System Proteins
  • Cell-Derived Microparticles
 

Citation

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Dye, J. R., Ullal, A. J., & Pisetsky, D. S. (2013). The role of microparticles in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. Scand J Immunol, 78(2), 140–148. https://doi.org/10.1111/sji.12068
Dye, J. R., A. J. Ullal, and D. S. Pisetsky. “The role of microparticles in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus.Scand J Immunol 78, no. 2 (August 2013): 140–48. https://doi.org/10.1111/sji.12068.
Dye JR, Ullal AJ, Pisetsky DS. The role of microparticles in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. Scand J Immunol. 2013 Aug;78(2):140–8.
Dye, J. R., et al. “The role of microparticles in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus.Scand J Immunol, vol. 78, no. 2, Aug. 2013, pp. 140–48. Pubmed, doi:10.1111/sji.12068.
Dye JR, Ullal AJ, Pisetsky DS. The role of microparticles in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. Scand J Immunol. 2013 Aug;78(2):140–148.
Journal cover image

Published In

Scand J Immunol

DOI

EISSN

1365-3083

Publication Date

August 2013

Volume

78

Issue

2

Start / End Page

140 / 148

Location

England

Related Subject Headings

  • Signal Transduction
  • Neovascularization, Pathologic
  • Lupus Erythematosus, Systemic
  • Joints
  • Immunology
  • Immunologic Factors
  • Humans
  • Cytokines
  • Complement System Proteins
  • Cell-Derived Microparticles