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Releasing the block: setting differentiation free with mutant IDH inhibitors.

Publication ,  Journal Article
Pirozzi, CJ; Reitman, ZJ; Yan, H
Published in: Cancer Cell
May 13, 2013

Hotspot mutations in IDH1 and IDH2 cause a differentiation block that can promote tumorigenesis. Two recent papers reported that small molecules targeting mutant IDH1 or mutant IDH2 release this differentiation block and/or impede tumor growth, providing a proof-of-concept that mutant IDHs are therapeutically targetable and that their effects are reversible.

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Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

May 13, 2013

Volume

23

Issue

5

Start / End Page

570 / 572

Location

United States

Related Subject Headings

  • Sulfonamides
  • Phenylurea Compounds
  • Oncology & Carcinogenesis
  • Leukemia, Myeloid, Acute
  • Isocitrate Dehydrogenase
  • Imidazoles
  • Humans
  • Hematopoiesis
  • Glioma
  • Enzyme Inhibitors
 

Citation

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ICMJE
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Pirozzi, C. J., Reitman, Z. J., & Yan, H. (2013). Releasing the block: setting differentiation free with mutant IDH inhibitors. Cancer Cell, 23(5), 570–572. https://doi.org/10.1016/j.ccr.2013.04.024
Pirozzi, Christopher J., Zachary J. Reitman, and Hai Yan. “Releasing the block: setting differentiation free with mutant IDH inhibitors.Cancer Cell 23, no. 5 (May 13, 2013): 570–72. https://doi.org/10.1016/j.ccr.2013.04.024.
Pirozzi CJ, Reitman ZJ, Yan H. Releasing the block: setting differentiation free with mutant IDH inhibitors. Cancer Cell. 2013 May 13;23(5):570–2.
Pirozzi, Christopher J., et al. “Releasing the block: setting differentiation free with mutant IDH inhibitors.Cancer Cell, vol. 23, no. 5, May 2013, pp. 570–72. Pubmed, doi:10.1016/j.ccr.2013.04.024.
Pirozzi CJ, Reitman ZJ, Yan H. Releasing the block: setting differentiation free with mutant IDH inhibitors. Cancer Cell. 2013 May 13;23(5):570–572.
Journal cover image

Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

May 13, 2013

Volume

23

Issue

5

Start / End Page

570 / 572

Location

United States

Related Subject Headings

  • Sulfonamides
  • Phenylurea Compounds
  • Oncology & Carcinogenesis
  • Leukemia, Myeloid, Acute
  • Isocitrate Dehydrogenase
  • Imidazoles
  • Humans
  • Hematopoiesis
  • Glioma
  • Enzyme Inhibitors