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Baseline platelet aggregation and major receptor expression predict subsequent activity following thrombolysis for acute myocardial infarction.

Publication ,  Journal Article
Gurbel, PA; Kereiakes, DJ; Atar, D; Serebruany, VL
Published in: Scand Cardiovasc J
2000

The early identification of patients with heightened platelet activity for aggressive antiplatelet regimens represents a critical clinical issue in acute myocardial infarction (AMI) therapy. We sought to determine whether the degree of pre-reperfusion platelet function is related to subsequent activity following thrombolysis. Platelets were investigated at baseline and at 24 h following thrombolytic therapy by aggregometry, and flow cytometry in 19 AMI patients enrolled in the GUSTO-III trial. Regression analysis revealed a significant correlation for 5 microM ADP (r2 = 0.529), 10 microM ADP (r2 = 0.445), thrombin (r2 = 0.226), collagen (r2 = 0.568), and ristocetin-induced aggregation (r2 = 0.964). Platelet expression linearly correlated for GPIIb/IIIa (r2 = 0.337), P-selectin (r = 0.817), PECAM-1 (r2 = 0.586), and the vitronectin receptor (r2 = 0.634). The data suggest that the baseline characteristics predict future platelet activity, and may prospectively identify patients who will benefit most from antiplatelet strategies after coronary thrombolysis.

Duke Scholars

Published In

Scand Cardiovasc J

DOI

ISSN

1401-7431

Publication Date

2000

Volume

34

Issue

1

Start / End Page

53 / 58

Location

England

Related Subject Headings

  • Thrombolytic Therapy
  • Receptors, Vitronectin
  • Prospective Studies
  • Prognosis
  • Platelet Membrane Glycoproteins
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Platelet Count
  • Platelet Aggregation Inhibitors
  • Platelet Aggregation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gurbel, P. A., Kereiakes, D. J., Atar, D., & Serebruany, V. L. (2000). Baseline platelet aggregation and major receptor expression predict subsequent activity following thrombolysis for acute myocardial infarction. Scand Cardiovasc J, 34(1), 53–58. https://doi.org/10.1080/14017430050142404
Gurbel, P. A., D. J. Kereiakes, D. Atar, and V. L. Serebruany. “Baseline platelet aggregation and major receptor expression predict subsequent activity following thrombolysis for acute myocardial infarction.Scand Cardiovasc J 34, no. 1 (2000): 53–58. https://doi.org/10.1080/14017430050142404.
Gurbel, P. A., et al. “Baseline platelet aggregation and major receptor expression predict subsequent activity following thrombolysis for acute myocardial infarction.Scand Cardiovasc J, vol. 34, no. 1, 2000, pp. 53–58. Pubmed, doi:10.1080/14017430050142404.
Journal cover image

Published In

Scand Cardiovasc J

DOI

ISSN

1401-7431

Publication Date

2000

Volume

34

Issue

1

Start / End Page

53 / 58

Location

England

Related Subject Headings

  • Thrombolytic Therapy
  • Receptors, Vitronectin
  • Prospective Studies
  • Prognosis
  • Platelet Membrane Glycoproteins
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Platelet Count
  • Platelet Aggregation Inhibitors
  • Platelet Aggregation