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Effect of thrombolytic therapy on platelet expression and plasma concentration of PECAM-1 (CD31) in patients with acute myocardial infarction.

Publication ,  Journal Article
Serebruany, VL; Gurbel, PA
Published in: Arterioscler Thromb Vasc Biol
January 1999

Animal studies have shown that the administration of antibodies against platelet/endothelial cell adhesion molecule-1 (PECAM-1) before reperfusion can reduce infarct size. The purpose of the present study was to define the effects of thrombolytic therapy in acute myocardial infarction (AMI) patients on the platelet expression and plasma concentrations of PECAM-1 at prespecified time points after attempted reperfusion. The plasma concentration and platelet expression of PECAM-1 were determined in 23 AMI patients enrolled in the Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO-III) trial before thrombolysis and at 3, 6, 12, and 24 hours thereafter and compared with 22 healthy controls. At baseline, PECAM-1 was expressed significantly more on the platelet surface in the AMI patients than in controls (P=0.027) while soluble PECAM-1 plasma levels were almost identical between groups. There were no significant diurnal variations in both plasma and platelet PECAM-1 levels in controls. A significant decrease in platelet PECAM-1 expression was observed 3 hours after thrombolysis (P=0.03) compared with baseline, followed by a significant increase (P=0.004) in fluorescence intensity later at 24 hours after thrombolysis. Conversely, a significant increase in soluble PECAM-1 was observed 3 hours after thrombolysis (P=0.02), followed by a significant decrease later at 24 hours after attempted reperfusion (P=0.03). The expression of platelet-bound PECAM-1 is increased in AMI patients. Discordantly directed changes in soluble and platelet PECAM-1 after the first 24 hours after thrombolytic therapy may represent redistribution of the whole PECAM-1 pool. Further investigation of the possible role of PECAM-1 and the relationship between its soluble and platelet fractions in AMI are warranted.

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Published In

Arterioscler Thromb Vasc Biol

DOI

ISSN

1079-5642

Publication Date

January 1999

Volume

19

Issue

1

Start / End Page

153 / 158

Location

United States

Related Subject Headings

  • Tissue Plasminogen Activator
  • Thrombolytic Therapy
  • Recombinant Proteins
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Plasminogen Activators
  • Myocardial Infarction
  • Male
  • Kinetics
  • Humans
  • Fibrinolytic Agents
 

Citation

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Serebruany, V. L., & Gurbel, P. A. (1999). Effect of thrombolytic therapy on platelet expression and plasma concentration of PECAM-1 (CD31) in patients with acute myocardial infarction. Arterioscler Thromb Vasc Biol, 19(1), 153–158. https://doi.org/10.1161/01.atv.19.1.153
Serebruany, V. L., and P. A. Gurbel. “Effect of thrombolytic therapy on platelet expression and plasma concentration of PECAM-1 (CD31) in patients with acute myocardial infarction.Arterioscler Thromb Vasc Biol 19, no. 1 (January 1999): 153–58. https://doi.org/10.1161/01.atv.19.1.153.
Serebruany, V. L., and P. A. Gurbel. “Effect of thrombolytic therapy on platelet expression and plasma concentration of PECAM-1 (CD31) in patients with acute myocardial infarction.Arterioscler Thromb Vasc Biol, vol. 19, no. 1, Jan. 1999, pp. 153–58. Pubmed, doi:10.1161/01.atv.19.1.153.

Published In

Arterioscler Thromb Vasc Biol

DOI

ISSN

1079-5642

Publication Date

January 1999

Volume

19

Issue

1

Start / End Page

153 / 158

Location

United States

Related Subject Headings

  • Tissue Plasminogen Activator
  • Thrombolytic Therapy
  • Recombinant Proteins
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Plasminogen Activators
  • Myocardial Infarction
  • Male
  • Kinetics
  • Humans
  • Fibrinolytic Agents