Skip to main content
Journal cover image

Treatment outcome of late steroid-resistant nephrotic syndrome: a study by the Midwest Pediatric Nephrology Consortium.

Publication ,  Journal Article
Straatmann, C; Ayoob, R; Gbadegesin, R; Gibson, K; Rheault, MN; Srivastava, T; Tran, CL; Gipson, DS; Greenbaum, LA; Smoyer, WE; Vehaskari, VM
Published in: Pediatr Nephrol
August 2013

BACKGROUND: Idiopathic nephrotic syndrome (NS) in children is classified as steroid sensitive or steroid resistant. Steroid sensitivity typically portends a low risk of permanent renal failure. However, some initially steroid-sensitive patients later develop steroid resistance. These patients with late steroid resistance (LSR) are often treated with immunosuppressant medications, but the effect of these additional drugs on the long-term prognosis of LSR is still unknown. METHODS: A retrospective chart review was performed on patients diagnosed with idiopathic NS and subsequent LSR during the 8-year study period from 2002 up to and including 2009, with a minimum of 2 years of follow-up. Primary outcome measures were proteinuria and renal function. RESULTS: A total of 29 patients were classified as having LSRNS. The majority of patients received treatment with calcineurin inhibitors and/or mycophenolate mofetil. Seven patients received three or more non-steroid immunosuppressant medications. Sustained complete or partial remission was achieved in 69 % of patients. Three developed end-stage renal disease, and all others maintained normal renal function. There were 13 episodes of serious adverse events, none of which were fatal or irreversible. CONCLUSION: Most patients with LSRNS responded to immunosuppressive therapy by reduction or resolution of proteinuria and preservation of renal function. The results suggest that immunosuppressive treatment is a viable option in NS patients who develop LSR.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Pediatr Nephrol

DOI

EISSN

1432-198X

Publication Date

August 2013

Volume

28

Issue

8

Start / End Page

1235 / 1241

Location

Germany

Related Subject Headings

  • Urology & Nephrology
  • Treatment Outcome
  • Time Factors
  • Retrospective Studies
  • Remission Induction
  • Proteinuria
  • Nephrotic Syndrome
  • Midwestern United States
  • Male
  • Kidney Failure, Chronic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Straatmann, C., Ayoob, R., Gbadegesin, R., Gibson, K., Rheault, M. N., Srivastava, T., … Vehaskari, V. M. (2013). Treatment outcome of late steroid-resistant nephrotic syndrome: a study by the Midwest Pediatric Nephrology Consortium. Pediatr Nephrol, 28(8), 1235–1241. https://doi.org/10.1007/s00467-013-2483-y
Straatmann, Caroline, Rose Ayoob, Rasheed Gbadegesin, Keisha Gibson, Michelle N. Rheault, Tarak Srivastava, Cheryl L. Tran, et al. “Treatment outcome of late steroid-resistant nephrotic syndrome: a study by the Midwest Pediatric Nephrology Consortium.Pediatr Nephrol 28, no. 8 (August 2013): 1235–41. https://doi.org/10.1007/s00467-013-2483-y.
Straatmann C, Ayoob R, Gbadegesin R, Gibson K, Rheault MN, Srivastava T, et al. Treatment outcome of late steroid-resistant nephrotic syndrome: a study by the Midwest Pediatric Nephrology Consortium. Pediatr Nephrol. 2013 Aug;28(8):1235–41.
Straatmann, Caroline, et al. “Treatment outcome of late steroid-resistant nephrotic syndrome: a study by the Midwest Pediatric Nephrology Consortium.Pediatr Nephrol, vol. 28, no. 8, Aug. 2013, pp. 1235–41. Pubmed, doi:10.1007/s00467-013-2483-y.
Straatmann C, Ayoob R, Gbadegesin R, Gibson K, Rheault MN, Srivastava T, Tran CL, Gipson DS, Greenbaum LA, Smoyer WE, Vehaskari VM. Treatment outcome of late steroid-resistant nephrotic syndrome: a study by the Midwest Pediatric Nephrology Consortium. Pediatr Nephrol. 2013 Aug;28(8):1235–1241.
Journal cover image

Published In

Pediatr Nephrol

DOI

EISSN

1432-198X

Publication Date

August 2013

Volume

28

Issue

8

Start / End Page

1235 / 1241

Location

Germany

Related Subject Headings

  • Urology & Nephrology
  • Treatment Outcome
  • Time Factors
  • Retrospective Studies
  • Remission Induction
  • Proteinuria
  • Nephrotic Syndrome
  • Midwestern United States
  • Male
  • Kidney Failure, Chronic