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Early-adulthood cardiovascular disease risk factor profiles among individuals with and without diabetes in the Framingham Heart Study.

Publication ,  Journal Article
Preis, SR; Pencina, MJ; Mann, DM; D'Agostino, RB; Savage, PJ; Fox, CS
Published in: Diabetes Care
June 2013

OBJECTIVE: Many studies of diabetes have examined risk factors at the time of diabetes diagnosis instead of considering the lifetime burden of adverse risk factor levels. We examined the 30-year cardiovascular disease (CVD) risk factor burden that participants have up to the time of diabetes diagnosis. RESEARCH DESIGN AND METHODS: Among participants free of CVD, incident diabetes cases (fasting plasma glucose ≥ 126 mg/dL or treatment) occurring at examinations 2 through 8 (1979-2008) of the Framingham Heart Study Offspring cohort were age- and sex-matched 1:2 to controls. CVD risk factors (hypertension, high LDL cholesterol, low HDL cholesterol, high triglycerides, obesity) were measured at the time of diabetes diagnosis and at time points 10, 20, and 30 years prior. Conditional logistic regression was used to compare risk factor levels at each time point between diabetes cases and controls. RESULTS: We identified 525 participants with new-onset diabetes who were matched to 1,049 controls (mean age, 60 years; 40% women). Compared with those without diabetes, individuals who eventually developed diabetes had higher levels of hypertension (odds ratio [OR], 2.2; P = 0.003), high LDL (OR, 1.5; P = 0.04), low HDL (OR, 2.1; P = 0.0001), high triglycerides (OR, 1.7; P = 0.04), and obesity (OR, 3.3; P < 0.0001) at time points 30 years before diabetes diagnosis. After further adjustment for BMI, the ORs for hypertension (OR, 1.9; P = 0.02) and low HDL (OR, 1.7; P = 0.01) remained statistically significant. CONCLUSIONS: CVD risk factors are increased up to 30 years before diagnosis of diabetes. These findings highlight the importance of a life course approach to CVD risk factor identification among individuals at risk for diabetes.

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Published In

Diabetes Care

DOI

EISSN

1935-5548

Publication Date

June 2013

Volume

36

Issue

6

Start / End Page

1590 / 1596

Location

United States

Related Subject Headings

  • Risk Factors
  • Middle Aged
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diabetes Mellitus
  • Cardiovascular Diseases
  • Aged
  • 42 Health sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Preis, S. R., Pencina, M. J., Mann, D. M., D’Agostino, R. B., Savage, P. J., & Fox, C. S. (2013). Early-adulthood cardiovascular disease risk factor profiles among individuals with and without diabetes in the Framingham Heart Study. Diabetes Care, 36(6), 1590–1596. https://doi.org/10.2337/dc12-1121
Preis, Sarah Rosner, Michael J. Pencina, Devin M. Mann, Ralph B. D’Agostino, Peter J. Savage, and Caroline S. Fox. “Early-adulthood cardiovascular disease risk factor profiles among individuals with and without diabetes in the Framingham Heart Study.Diabetes Care 36, no. 6 (June 2013): 1590–96. https://doi.org/10.2337/dc12-1121.
Preis SR, Pencina MJ, Mann DM, D’Agostino RB, Savage PJ, Fox CS. Early-adulthood cardiovascular disease risk factor profiles among individuals with and without diabetes in the Framingham Heart Study. Diabetes Care. 2013 Jun;36(6):1590–6.
Preis, Sarah Rosner, et al. “Early-adulthood cardiovascular disease risk factor profiles among individuals with and without diabetes in the Framingham Heart Study.Diabetes Care, vol. 36, no. 6, June 2013, pp. 1590–96. Pubmed, doi:10.2337/dc12-1121.
Preis SR, Pencina MJ, Mann DM, D’Agostino RB, Savage PJ, Fox CS. Early-adulthood cardiovascular disease risk factor profiles among individuals with and without diabetes in the Framingham Heart Study. Diabetes Care. 2013 Jun;36(6):1590–1596.

Published In

Diabetes Care

DOI

EISSN

1935-5548

Publication Date

June 2013

Volume

36

Issue

6

Start / End Page

1590 / 1596

Location

United States

Related Subject Headings

  • Risk Factors
  • Middle Aged
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diabetes Mellitus
  • Cardiovascular Diseases
  • Aged
  • 42 Health sciences