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Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study.

Publication ,  Journal Article
Jasuja, GK; Travison, TG; Davda, M; Murabito, JM; Basaria, S; Zhang, A; Kushnir, MM; Rockwood, AL; Meikle, W; Pencina, MJ; Coviello, A ...
Published in: J Gerontol A Biol Sci Med Sci
June 2013

BACKGROUND: Age trends in estradiol and estrone levels in men and how lifestyle factors, comorbid conditions, testosterone, and sex hormone-binding globulin affect these age trends remain poorly understood, and were examined in men of the Framingham Heart Study. METHODS: Estrone and estradiol concentrations were measured in morning fasting samples using liquid chromatography tandem mass spectrometry in men of Framingham Offspring Generation. Free estradiol was calculated using a law of mass action equation. RESULTS: There were 1,461 eligible men (mean age [±SD] 61.1±9.5 years and body mass index [BMI] 28.8±4.5kg/m(2)). Total estradiol and estrone were positively associated with age, but free estradiol was negatively associated with age. Age-related increase in total estrone was greater than that in total estradiol. Estrone was positively associated with smoking, BMI, and testosterone, and total and free estradiol with diabetes, BMI, testosterone, and comorbid conditions; additionally, free estradiol was associated negatively with smoking. Collectively, age, BMI, testosterone, and other health and behavioral factors explained only 18% of variance in estradiol, and 9% of variance in estrone levels. Men in the highest quintile of estrone levels had significantly higher age and BMI, and a higher prevalence of smoking, diabetes, and cardiovascular disease than others, whereas those in the highest quintile of estradiol had higher BMI than others. CONCLUSIONS: Total estrone and estradiol levels in men, measured using liquid chromatography tandem mass spectrometry, revealed significant age-related increases that were only partially accounted for by cross-sectional differences in BMI, diabetes status, and other comorbidities and health behaviors. Longitudinal studies are needed to confirm these findings.

Duke Scholars

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

June 2013

Volume

68

Issue

6

Start / End Page

733 / 740

Location

United States

Related Subject Headings

  • Testosterone
  • Tandem Mass Spectrometry
  • Smoking
  • Sex Hormone-Binding Globulin
  • Risk Factors
  • Prevalence
  • Obesity
  • Middle Aged
  • Male
  • Life Style
 

Citation

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Jasuja, G. K., Travison, T. G., Davda, M., Murabito, J. M., Basaria, S., Zhang, A., … Bhasin, S. (2013). Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study. J Gerontol A Biol Sci Med Sci, 68(6), 733–740. https://doi.org/10.1093/gerona/gls216
Jasuja, Guneet Kaur, Thomas G. Travison, Maithili Davda, Joanne M. Murabito, Shehzad Basaria, Anqi Zhang, Mark M. Kushnir, et al. “Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study.J Gerontol A Biol Sci Med Sci 68, no. 6 (June 2013): 733–40. https://doi.org/10.1093/gerona/gls216.
Jasuja GK, Travison TG, Davda M, Murabito JM, Basaria S, Zhang A, et al. Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study. J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):733–40.
Jasuja, Guneet Kaur, et al. “Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study.J Gerontol A Biol Sci Med Sci, vol. 68, no. 6, June 2013, pp. 733–40. Pubmed, doi:10.1093/gerona/gls216.
Jasuja GK, Travison TG, Davda M, Murabito JM, Basaria S, Zhang A, Kushnir MM, Rockwood AL, Meikle W, Pencina MJ, Coviello A, Rose AJ, D’Agostino R, Vasan RS, Bhasin S. Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study. J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):733–740.
Journal cover image

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

June 2013

Volume

68

Issue

6

Start / End Page

733 / 740

Location

United States

Related Subject Headings

  • Testosterone
  • Tandem Mass Spectrometry
  • Smoking
  • Sex Hormone-Binding Globulin
  • Risk Factors
  • Prevalence
  • Obesity
  • Middle Aged
  • Male
  • Life Style