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Circulating plasma cholesteryl ester transfer protein activity and blood pressure tracking in the community.

Publication ,  Journal Article
Zachariah, JP; Pencina, MJ; Lyass, A; Kaur, G; D'Agostino, RB; Ordovas, JM; Vasan, RS
Published in: J Hypertens
May 2011

OBJECTIVE: Clinical trials using cholesteryl ester transfer protein (CETP) inhibitors to raise high-density lipoprotein cholesterol (HDL-C) concentrations reported an 'off-target' blood pressure (BP) raising effect. We evaluated the relations of baseline plasma CETP activity and longitudinal BP change. METHODS AND RESULTS: One thousand, three hundred and seven Framingham Study participants free of cardiovascular disease attending consecutive examinations 4 years apart (mean age 48 years) had baseline plasma CETP activity related to change in BP over the 4-year interval, adjusting for standard risk factors. Systolic BP increased [median +2 mmHg, 95% confidence interval (CI) -16,+23 mmHg], whereas diastolic BP decreased (median -3 mmHg, 95% CI -15,+11 mmHg). Plasma CETP activity was not related to change in diastolic BP, but was inversely related to change in systolic BP that was borderline significant (P=0.09). On multivariable analyses, plasma CETP activity was inversely related to change in pulse pressure (PP; beta per SD increment= -0.71 mmHg, P=0.005). When dichotomized at the median, plasma CETP activity above the median was associated with a 1 mmHg lower PP on follow-up (P=0.045). CONCLUSION: Decreasing plasma CETP activity was modestly related to increasing PP on follow-up in our community-based sample, suggesting that inhibition of intrinsic CETP activity itself is likely associated with minimal changes in BP.

Duke Scholars

Published In

J Hypertens

DOI

EISSN

1473-5598

Publication Date

May 2011

Volume

29

Issue

5

Start / End Page

863 / 868

Location

Netherlands

Related Subject Headings

  • Multivariate Analysis
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cholesterol Ester Transfer Proteins
  • Cardiovascular System & Hematology
  • Blood Pressure
  • Adult
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Zachariah, J. P., Pencina, M. J., Lyass, A., Kaur, G., D’Agostino, R. B., Ordovas, J. M., & Vasan, R. S. (2011). Circulating plasma cholesteryl ester transfer protein activity and blood pressure tracking in the community. J Hypertens, 29(5), 863–868. https://doi.org/10.1097/HJH.0b013e3283450223
Zachariah, Justin P., Michael J. Pencina, Asya Lyass, Guneet Kaur, Ralph B. D’Agostino, Jose M. Ordovas, and Ramachandran S. Vasan. “Circulating plasma cholesteryl ester transfer protein activity and blood pressure tracking in the community.J Hypertens 29, no. 5 (May 2011): 863–68. https://doi.org/10.1097/HJH.0b013e3283450223.
Zachariah JP, Pencina MJ, Lyass A, Kaur G, D’Agostino RB, Ordovas JM, et al. Circulating plasma cholesteryl ester transfer protein activity and blood pressure tracking in the community. J Hypertens. 2011 May;29(5):863–8.
Zachariah, Justin P., et al. “Circulating plasma cholesteryl ester transfer protein activity and blood pressure tracking in the community.J Hypertens, vol. 29, no. 5, May 2011, pp. 863–68. Pubmed, doi:10.1097/HJH.0b013e3283450223.
Zachariah JP, Pencina MJ, Lyass A, Kaur G, D’Agostino RB, Ordovas JM, Vasan RS. Circulating plasma cholesteryl ester transfer protein activity and blood pressure tracking in the community. J Hypertens. 2011 May;29(5):863–868.

Published In

J Hypertens

DOI

EISSN

1473-5598

Publication Date

May 2011

Volume

29

Issue

5

Start / End Page

863 / 868

Location

Netherlands

Related Subject Headings

  • Multivariate Analysis
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cholesterol Ester Transfer Proteins
  • Cardiovascular System & Hematology
  • Blood Pressure
  • Adult
  • 3202 Clinical sciences