Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT.

Publication ,  Journal Article
Polak, JF; Pencina, MJ; Meisner, A; Pencina, KM; Brown, LS; Wolf, PA; D'Agostino, RB
Published in: J Ultrasound Med
December 2010

OBJECTIVE: The goal of this study was to compare internal carotid artery (ICA) intima-media thickness (IMT) with common carotid artery (CCA) IMT as global markers of cardiovascular disease (CVD). METHODS: Cross-sectional measurements of the mean CCA IMT and maximum ICA IMT were made on ultrasound images acquired from the Framingham Offspring cohort (n = 3316; mean age, 58 years; 52.7% women). Linear regression models were used to study the associations of the Framingham risk factors with CCA and ICA IMT. Multivariate logistic regression models and receiver operating characteristic (ROC) curve analysis were used to compare the associations of prevalent CVD with CCA and ICA IMT and determine sensitivity and specificity. RESULTS: The association between age and the mean CCA IMT corresponded to an increase of 0.007 mm/y; the increase was 0.037 mm/y for the ICA IMT. Framingham risk factors accounted for 28.6% and 27.5% of the variability in the CCA and ICA IMT, respectively. Age and gender contributed 23.5% to the variability of the CCA IMT and 22.5% to that of the ICA IMT, with the next most important factor being systolic blood pressure (1.9%) for the CCA IMT and smoking (1.6%) for the ICA IMT. The CCA IMT and ICA IMT were statistically significant predictors of prevalent CVD, with the ICA IMT having a larger area under the ROC curve (0.756 versus 0.695). CONCLUSIONS: Associations of risk factors with CCA and ICA IMT are slightly different, and both are independently associated with prevalent CVD. Their value for predicting incident cardiovascular events needs to be compared in outcome studies.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Ultrasound Med

DOI

EISSN

1550-9613

Publication Date

December 2010

Volume

29

Issue

12

Start / End Page

1759 / 1768

Location

England

Related Subject Headings

  • Ultrasonography, Doppler
  • Tunica Media
  • Tunica Intima
  • Risk Factors
  • Risk Assessment
  • ROC Curve
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Logistic Models
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Polak, J. F., Pencina, M. J., Meisner, A., Pencina, K. M., Brown, L. S., Wolf, P. A., & D’Agostino, R. B. (2010). Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT. J Ultrasound Med, 29(12), 1759–1768. https://doi.org/10.7863/jum.2010.29.12.1759
Polak, Joseph F., Michael J. Pencina, Allison Meisner, Karol M. Pencina, Lisa S. Brown, Philip A. Wolf, and Ralph B. D’Agostino. “Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT.J Ultrasound Med 29, no. 12 (December 2010): 1759–68. https://doi.org/10.7863/jum.2010.29.12.1759.

Published In

J Ultrasound Med

DOI

EISSN

1550-9613

Publication Date

December 2010

Volume

29

Issue

12

Start / End Page

1759 / 1768

Location

England

Related Subject Headings

  • Ultrasonography, Doppler
  • Tunica Media
  • Tunica Intima
  • Risk Factors
  • Risk Assessment
  • ROC Curve
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Logistic Models