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Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the framingham offspring study.

Publication ,  Journal Article
Lieb, W; Xanthakis, V; Sullivan, LM; Aragam, J; Pencina, MJ; Larson, MG; Benjamin, EJ; Vasan, RS
Published in: Circulation
June 23, 2009

BACKGROUND: Information is limited on the longitudinal tracking of left ventricular (LV) mass over the adult life course and the determinants of such change. METHODS AND RESULTS: We used multilevel modeling to evaluate the correlates of LV mass prospectively over a 16-year period in 4217 Framingham study participants (mean age 45 years, 53% women) using up to 4 serial routine echocardiographic observations on each individual (11 762 observations). Age, sex, body mass index, systolic blood pressure, antihypertensive treatment, smoking, and diabetes mellitus were related to longitudinal measures of LV mass. Women and participants with diabetes mellitus experienced a steeper increase in LV mass with advancing age (compared with men and those without diabetes mellitus; P for interactions <0.0001 and 0.0003, respectively). Women also displayed greater increments in LV mass with increasing body mass index (compared with men, P=0.04 for interaction). Participants with optimal values of these risk factors experienced lesser increases in LV mass over time. Analyses evaluating short-term (4-year) changes in LV mass (2605 unique individuals providing 4494 observations) identified the same key determinants that influenced its long-term trajectory (ie, body mass index, sex, systolic blood pressure, antihypertensive treatment, and smoking). CONCLUSIONS: Our longitudinal observations on a large community-based sample identified higher blood pressure, excess adiposity, smoking, and diabetes mellitus as fundamental determinants of LV mass tracking over the adult life course. These observations are consistent with the notion that maintenance of optimal levels of these risk factors in midlife will reduce the burden of LV hypertrophy, and possibly heart failure, in older age.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

June 23, 2009

Volume

119

Issue

24

Start / End Page

3085 / 3092

Location

United States

Related Subject Headings

  • Time Factors
  • Sex Factors
  • Risk Factors
  • Organ Size
  • Middle Aged
  • Massachusetts
  • Male
  • Hypertrophy, Left Ventricular
  • Humans
  • Heart Ventricles
 

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Lieb, W., Xanthakis, V., Sullivan, L. M., Aragam, J., Pencina, M. J., Larson, M. G., … Vasan, R. S. (2009). Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the framingham offspring study. Circulation, 119(24), 3085–3092. https://doi.org/10.1161/CIRCULATIONAHA.108.824243
Lieb, Wolfgang, Vanessa Xanthakis, Lisa M. Sullivan, Jayashri Aragam, Michael J. Pencina, Martin G. Larson, Emelia J. Benjamin, and Ramachandran S. Vasan. “Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the framingham offspring study.Circulation 119, no. 24 (June 23, 2009): 3085–92. https://doi.org/10.1161/CIRCULATIONAHA.108.824243.
Lieb W, Xanthakis V, Sullivan LM, Aragam J, Pencina MJ, Larson MG, et al. Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the framingham offspring study. Circulation. 2009 Jun 23;119(24):3085–92.
Lieb, Wolfgang, et al. “Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the framingham offspring study.Circulation, vol. 119, no. 24, June 2009, pp. 3085–92. Pubmed, doi:10.1161/CIRCULATIONAHA.108.824243.
Lieb W, Xanthakis V, Sullivan LM, Aragam J, Pencina MJ, Larson MG, Benjamin EJ, Vasan RS. Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the framingham offspring study. Circulation. 2009 Jun 23;119(24):3085–3092.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

June 23, 2009

Volume

119

Issue

24

Start / End Page

3085 / 3092

Location

United States

Related Subject Headings

  • Time Factors
  • Sex Factors
  • Risk Factors
  • Organ Size
  • Middle Aged
  • Massachusetts
  • Male
  • Hypertrophy, Left Ventricular
  • Humans
  • Heart Ventricles