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Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community.

Publication ,  Journal Article
Joseph, J; Pencina, MJ; Wang, TJ; Hayes, L; Tofler, GH; Jacques, P; Selhub, J; Levy, D; D'Agostino, RB; Benjamin, EJ; Vasan, RS
Published in: J Hypertens
June 2009

OBJECTIVE: Hyperhomocysteinemia, neurohormonal activation, inflammation and altered fibrinolysis have been linked to atherothrombosis as well as to myocardial fibrosis and heart failure. Hence, we related a panel of biomarkers representing these pathways to plasma markers of collagen metabolism in a large community-based sample. METHODS: We related nine biomarkers representing select biologic pathways (independent variables: C-reactive protein, B-type natriuretic peptide, N-terminal proatrial natriuretic peptide, aldosterone, renin, fibrinogen, D-dimer, plasminogen activator inhibitor-1 and homocysteine) to three plasma markers of collagen turnover [dependent variables, separate models for each: aminoterminal propeptide of type III collagen, tissue inhibitor of metalloproteinases-1 and matrix metalloproteinase-9 (present versus absent)] in 921 Framingham Heart study participants (mean age 57 years; 58% women). Participants were separated a priori into those with left ventricular end-diastolic dimensions and wall thickness below sex-specific median values (referent group) and either measure at least 90th sex-specific percentile ('remodeled' group). We used stepwise multivariable regression analysis adjusting for cardiovascular risk factors to relate the panel of systemic biomarkers to the three biomarkers of collagen metabolism. RESULTS: Plasma homocysteine was positively related to all three markers of collagen metabolism in the remodeled group and to aminoterminal propeptide of type III collagen and tissue inhibitor of metalloproteinases-1 in the referent group. Plasminogen activator inhibitor-1 was positively related to aminoterminal propeptide of type III collagen and tissue inhibitor of metalloproteinases-1 in both groups, whereas the natriuretic peptides were associated positively with these collagen markers in the referent group. CONCLUSION: In our large community-based sample, plasma homocysteine and plasminogen activator inhibitor-1 were positively related to circulating collagen biomarkers, consistent with experimental studies implicating these pathways in cardiovascular collagen turnover.

Duke Scholars

Published In

J Hypertens

DOI

EISSN

1473-5598

Publication Date

June 2009

Volume

27

Issue

6

Start / End Page

1317 / 1324

Location

Netherlands

Related Subject Headings

  • Ventricular Remodeling
  • Tissue Inhibitor of Metalloproteinase-1
  • Renin-Angiotensin System
  • Renin
  • Protein Precursors
  • Plasminogen Activator Inhibitor 1
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Matrix Metalloproteinase 9
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Joseph, J., Pencina, M. J., Wang, T. J., Hayes, L., Tofler, G. H., Jacques, P., … Vasan, R. S. (2009). Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community. J Hypertens, 27(6), 1317–1324. https://doi.org/10.1097/HJH.0b013e328329fc20
Joseph, Jacob, Michael J. Pencina, Thomas J. Wang, Laura Hayes, Geoffrey H. Tofler, Paul Jacques, Jacob Selhub, et al. “Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community.J Hypertens 27, no. 6 (June 2009): 1317–24. https://doi.org/10.1097/HJH.0b013e328329fc20.
Joseph J, Pencina MJ, Wang TJ, Hayes L, Tofler GH, Jacques P, et al. Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community. J Hypertens. 2009 Jun;27(6):1317–24.
Joseph, Jacob, et al. “Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community.J Hypertens, vol. 27, no. 6, June 2009, pp. 1317–24. Pubmed, doi:10.1097/HJH.0b013e328329fc20.
Joseph J, Pencina MJ, Wang TJ, Hayes L, Tofler GH, Jacques P, Selhub J, Levy D, D’Agostino RB, Benjamin EJ, Vasan RS. Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community. J Hypertens. 2009 Jun;27(6):1317–1324.

Published In

J Hypertens

DOI

EISSN

1473-5598

Publication Date

June 2009

Volume

27

Issue

6

Start / End Page

1317 / 1324

Location

Netherlands

Related Subject Headings

  • Ventricular Remodeling
  • Tissue Inhibitor of Metalloproteinase-1
  • Renin-Angiotensin System
  • Renin
  • Protein Precursors
  • Plasminogen Activator Inhibitor 1
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Matrix Metalloproteinase 9
  • Male