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Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005.

Publication ,  Journal Article
Preis, SR; Hwang, S-J; Coady, S; Pencina, MJ; D'Agostino, RB; Savage, PJ; Levy, D; Fox, CS
Published in: Circulation
April 7, 2009

BACKGROUND: Despite population declines in all-cause mortality, women with diabetes mellitus may have experienced an increase in mortality rates compared with men. METHODS AND RESULTS: We examined change in all-cause, cardiovascular, and non-cardiovascular disease mortality rates among Framingham Heart Study participants who attended examinations during an "earlier" (1950 to 1975; n=930 deaths) and a "later" (1976 to 2001; n=773 deaths) time period. Diabetes mellitus was defined as casual glucose > or =200 mg/dL, fasting plasma glucose > or =126 mg/dL, or treatment. Among women, the hazard ratios (HRs) for all-cause mortality in the later versus the earlier time period were 0.59 (95% confidence interval, 0.50 to 0.70; P<0.0001) for those without diabetes mellitus and 0.48 (95% confidence interval, 0.32 to 0.71; P=0.002) for those with diabetes mellitus. Similar results were observed in men. Among women and men, the HR of cardiovascular disease mortality declined among those with and without diabetes mellitus. Non-cardiovascular disease mortality declined among women without diabetes mellitus (HR, 0.76; P=0.01), whereas no change was observed among women with diabetes mellitus or among men with or without diabetes mellitus. Individuals with versus those without diabetes mellitus were at increased risk of all-cause mortality in the earlier (HR, 2.44; P<0.0001) and later (HR, 1.95; P<0.0001) time periods. CONCLUSIONS: Reductions in all-cause mortality among women and men with diabetes mellitus have occurred over time. However, mortality rates among individuals with diabetes mellitus remain approximately 2-fold higher compared with individuals without diabetes mellitus.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

April 7, 2009

Volume

119

Issue

13

Start / End Page

1728 / 1735

Location

United States

Related Subject Headings

  • Sex Distribution
  • Risk Factors
  • Middle Aged
  • Massachusetts
  • Male
  • Humans
  • Follow-Up Studies
  • Female
  • Diabetes Mellitus, Type 2
  • Diabetes Mellitus, Type 1
 

Citation

APA
Chicago
ICMJE
MLA
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Preis, S. R., Hwang, S.-J., Coady, S., Pencina, M. J., D’Agostino, R. B., Savage, P. J., … Fox, C. S. (2009). Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005. Circulation, 119(13), 1728–1735. https://doi.org/10.1161/CIRCULATIONAHA.108.829176
Preis, Sarah Rosner, Shih-Jen Hwang, Sean Coady, Michael J. Pencina, Ralph B. D’Agostino, Peter J. Savage, Daniel Levy, and Caroline S. Fox. “Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005.Circulation 119, no. 13 (April 7, 2009): 1728–35. https://doi.org/10.1161/CIRCULATIONAHA.108.829176.
Preis SR, Hwang S-J, Coady S, Pencina MJ, D’Agostino RB, Savage PJ, et al. Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005. Circulation. 2009 Apr 7;119(13):1728–35.
Preis, Sarah Rosner, et al. “Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005.Circulation, vol. 119, no. 13, Apr. 2009, pp. 1728–35. Pubmed, doi:10.1161/CIRCULATIONAHA.108.829176.
Preis SR, Hwang S-J, Coady S, Pencina MJ, D’Agostino RB, Savage PJ, Levy D, Fox CS. Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005. Circulation. 2009 Apr 7;119(13):1728–1735.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

April 7, 2009

Volume

119

Issue

13

Start / End Page

1728 / 1735

Location

United States

Related Subject Headings

  • Sex Distribution
  • Risk Factors
  • Middle Aged
  • Massachusetts
  • Male
  • Humans
  • Follow-Up Studies
  • Female
  • Diabetes Mellitus, Type 2
  • Diabetes Mellitus, Type 1