Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Relations of matrix remodeling biomarkers to blood pressure progression and incidence of hypertension in the community.

Publication ,  Journal Article
Dhingra, R; Pencina, MJ; Schrader, P; Wang, TJ; Levy, D; Pencina, K; Siwik, DA; Colucci, WS; Benjamin, EJ; Vasan, RS
Published in: Circulation
March 3, 2009

BACKGROUND: Biomarkers of extracellular matrix remodeling are associated with prevalent hypertension in cross-sectional studies, but their relations to longitudinal changes in blood pressure (BP) and hypertension incidence are unknown. METHODS AND RESULTS: We evaluated 595 nonhypertensive Framingham Offspring Study participants (mean age 55 years; 360 women) without prior heart failure or myocardial infarction who underwent routine measurements of plasma tissue inhibitor of metalloproteinase-1 (TIMP-1), metalloproteinase-9 (MMP-9), and procollagen III N-terminal peptide. We related plasma TIMP-1, procollagen III N-terminal peptide, and MMP-9 to the incidence of hypertension and progression of BP by >or=1 category (defined on the basis of the sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure). On follow-up (4 years), 81 participants (51 women) developed hypertension, and 198 (114 women) progressed to a higher BP category. In multivariable models, a 1-SD increment of log-TIMP-1 was associated with a 50% higher incidence of hypertension (95% CI 1.08 to 2.08) and a 21% (95% CI 1.00 to 1.47) higher risk of BP progression. Individuals in the top TIMP-1 tertile had a 2.15-fold increased risk of hypertension (95% CI 0.99 to 4.68) and 1.68-fold (95% CI 1.05 to 2.70) increased risk of BP progression relative to the lowest tertile. Individuals with detectable MMP-9 had a 1.97-fold higher risk of BP progression (95% CI 1.06 to 3.64) than those with undetectable levels. Plasma procollagen III N-terminal peptide was not associated with hypertension incidence or BP progression. CONCLUSIONS: In the present community-based sample, higher TIMP-1 and MMP-9 concentrations were associated with BP progression on follow-up. Additional studies are warranted to confirm our findings.

Duke Scholars

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

March 3, 2009

Volume

119

Issue

8

Start / End Page

1101 / 1107

Location

United States

Related Subject Headings

  • Risk Factors
  • Middle Aged
  • Massachusetts
  • Male
  • Incidence
  • Hypertension
  • Humans
  • Follow-Up Studies
  • Female
  • Extracellular Matrix
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dhingra, R., Pencina, M. J., Schrader, P., Wang, T. J., Levy, D., Pencina, K., … Vasan, R. S. (2009). Relations of matrix remodeling biomarkers to blood pressure progression and incidence of hypertension in the community. Circulation, 119(8), 1101–1107. https://doi.org/10.1161/CIRCULATIONAHA.108.821769
Dhingra, Ravi, Michael J. Pencina, Peter Schrader, Thomas J. Wang, Daniel Levy, Karol Pencina, Deborah A. Siwik, Wilson S. Colucci, Emelia J. Benjamin, and Ramachandran S. Vasan. “Relations of matrix remodeling biomarkers to blood pressure progression and incidence of hypertension in the community.Circulation 119, no. 8 (March 3, 2009): 1101–7. https://doi.org/10.1161/CIRCULATIONAHA.108.821769.
Dhingra R, Pencina MJ, Schrader P, Wang TJ, Levy D, Pencina K, et al. Relations of matrix remodeling biomarkers to blood pressure progression and incidence of hypertension in the community. Circulation. 2009 Mar 3;119(8):1101–7.
Dhingra, Ravi, et al. “Relations of matrix remodeling biomarkers to blood pressure progression and incidence of hypertension in the community.Circulation, vol. 119, no. 8, Mar. 2009, pp. 1101–07. Pubmed, doi:10.1161/CIRCULATIONAHA.108.821769.
Dhingra R, Pencina MJ, Schrader P, Wang TJ, Levy D, Pencina K, Siwik DA, Colucci WS, Benjamin EJ, Vasan RS. Relations of matrix remodeling biomarkers to blood pressure progression and incidence of hypertension in the community. Circulation. 2009 Mar 3;119(8):1101–1107.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

March 3, 2009

Volume

119

Issue

8

Start / End Page

1101 / 1107

Location

United States

Related Subject Headings

  • Risk Factors
  • Middle Aged
  • Massachusetts
  • Male
  • Incidence
  • Hypertension
  • Humans
  • Follow-Up Studies
  • Female
  • Extracellular Matrix