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Vitamin E supplement use and the incidence of cardiovascular disease and all-cause mortality in the Framingham Heart Study: Does the underlying health status play a role?

Publication ,  Journal Article
Dietrich, M; Jacques, PF; Pencina, MJ; Lanier, K; Keyes, MJ; Kaur, G; Wolf, PA; D'Agostino, RB; Vasan, RS
Published in: Atherosclerosis
August 2009

BACKGROUND: Observational studies generally showed beneficial associations between supplemental vitamin E intake and cardiovascular disease (CVD) risk whereas intervention trials reported adverse effects of vitamin E supplements. We hypothesize that these discordant findings result from differing underlying health status of study participants in observational and intervention studies. OBJECTIVE: Determine if the relation between supplemental vitamin E intake and CVD and all-cause mortality (ACM) depends on pre-existing CVD. DESIGN: Proportional hazards regression to relate supplemental vitamin E intake to the 10-year incidence of CVD and ACM in 4270 Framingham Study participants stratified by baseline CVD status. RESULTS: Eleven percent of participants used vitamin E supplements at baseline. In participants with pre-existing CVD, there were 28 (44%) and 20 (32%) incident cases of CVD and ACM in the vitamin E supplement users versus 249 (47%) and 202 (38%) in the non-users, respectively (CVD HR, 0.90; 95% CL, 0.60-1.32; ACM HR, 0.74; 95% CL, 0.46-1.17). In participants without pre-existing CVD, there were 51 (13%) and 47 (12%) cases of CVD and ACM in the vitamin E supplement group versus 428 (13%) and 342 (10%) in the non-vitamin E supplement group, respectively (CVD HR, 1.00; 95% CL, 0.75-1.34; ACM HR 1.20; 95% CL, 0.89-1.64). CONCLUSION: CVD status has no apparent influence on the association of supplemental vitamin E intake and risk for CVD and ACM in this large, community-based study. Further research is needed to clarify the basis for the discrepant results between intervention and observational studies of supplemental vitamin E intake.

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Published In

Atherosclerosis

DOI

EISSN

1879-1484

Publication Date

August 2009

Volume

205

Issue

2

Start / End Page

549 / 553

Location

Ireland

Related Subject Headings

  • Vitamin E
  • Risk
  • Prospective Studies
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Humans
  • Female
  • Dietary Supplements
  • Cohort Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Dietrich, M., Jacques, P. F., Pencina, M. J., Lanier, K., Keyes, M. J., Kaur, G., … Vasan, R. S. (2009). Vitamin E supplement use and the incidence of cardiovascular disease and all-cause mortality in the Framingham Heart Study: Does the underlying health status play a role? Atherosclerosis, 205(2), 549–553. https://doi.org/10.1016/j.atherosclerosis.2008.12.019
Dietrich, M., P. F. Jacques, M. J. Pencina, K. Lanier, M. J. Keyes, G. Kaur, P. A. Wolf, R. B. D’Agostino, and R. S. Vasan. “Vitamin E supplement use and the incidence of cardiovascular disease and all-cause mortality in the Framingham Heart Study: Does the underlying health status play a role?Atherosclerosis 205, no. 2 (August 2009): 549–53. https://doi.org/10.1016/j.atherosclerosis.2008.12.019.
Dietrich M, Jacques PF, Pencina MJ, Lanier K, Keyes MJ, Kaur G, et al. Vitamin E supplement use and the incidence of cardiovascular disease and all-cause mortality in the Framingham Heart Study: Does the underlying health status play a role? Atherosclerosis. 2009 Aug;205(2):549–53.
Dietrich, M., et al. “Vitamin E supplement use and the incidence of cardiovascular disease and all-cause mortality in the Framingham Heart Study: Does the underlying health status play a role?Atherosclerosis, vol. 205, no. 2, Aug. 2009, pp. 549–53. Pubmed, doi:10.1016/j.atherosclerosis.2008.12.019.
Dietrich M, Jacques PF, Pencina MJ, Lanier K, Keyes MJ, Kaur G, Wolf PA, D’Agostino RB, Vasan RS. Vitamin E supplement use and the incidence of cardiovascular disease and all-cause mortality in the Framingham Heart Study: Does the underlying health status play a role? Atherosclerosis. 2009 Aug;205(2):549–553.
Journal cover image

Published In

Atherosclerosis

DOI

EISSN

1879-1484

Publication Date

August 2009

Volume

205

Issue

2

Start / End Page

549 / 553

Location

Ireland

Related Subject Headings

  • Vitamin E
  • Risk
  • Prospective Studies
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Humans
  • Female
  • Dietary Supplements
  • Cohort Studies