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Prevalence, clinical correlates, and prognosis of discrete upper septal thickening on echocardiography: the Framingham Heart Study.

Publication ,  Journal Article
Diaz, T; Pencina, MJ; Benjamin, EJ; Aragam, J; Fuller, DL; Pencina, KM; Levy, D; Vasan, RS
Published in: Echocardiography
March 2009

The upper interventricular septum may be prominent in elderly individuals, a finding referred to as discrete upper septal thickening (DUST). We examined the prevalence, clinical and echocardiographic correlates, and prognostic significance of DUST in a community-based sample. We evaluated Framingham Study participants who underwent routine echocardiography. In 3562 Framingham Study participants (mean age 58 years, 57% women), DUST was observed in 52 participants. The clinical correlates of DUST were increasing age (odds ratio [OR] per 10 year increment 2.59, 95% confidence intervals [CI] 1.64-4.08) and systolic blood pressure (OR per SD increment 1.55, 95% CI 1.15-2.09). DUST was positively associated with left ventricular (LV) fractional shortening and mitral annular calcification but inversely with LV diastolic dimensions (P < 0.02 for all). On follow-up (mean 15 years), 732 individuals died (33 with DUST) and 560 experienced a cardiovascular disease (CVD) event (18 with DUST). Adjusting for cardiovascular risk factors, DUST was not associated with CVD or mortality risk (P > 0.30 for both). The follow-up component of our study suggests that DUST is not independently associated with adverse prognosis.

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Published In

Echocardiography

DOI

EISSN

1540-8175

Publication Date

March 2009

Volume

26

Issue

3

Start / End Page

247 / 253

Location

United States

Related Subject Headings

  • Statistics as Topic
  • Sensitivity and Specificity
  • Risk Factors
  • Risk Assessment
  • Reproducibility of Results
  • Prognosis
  • Prevalence
  • Middle Aged
  • Massachusetts
  • Male
 

Citation

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Diaz, T., Pencina, M. J., Benjamin, E. J., Aragam, J., Fuller, D. L., Pencina, K. M., … Vasan, R. S. (2009). Prevalence, clinical correlates, and prognosis of discrete upper septal thickening on echocardiography: the Framingham Heart Study. Echocardiography, 26(3), 247–253. https://doi.org/10.1111/j.1540-8175.2008.00806.x
Diaz, Tulio, Michael J. Pencina, Emelia J. Benjamin, Jayashri Aragam, Deborah L. Fuller, Karol M. Pencina, Daniel Levy, and Ramachandran S. Vasan. “Prevalence, clinical correlates, and prognosis of discrete upper septal thickening on echocardiography: the Framingham Heart Study.Echocardiography 26, no. 3 (March 2009): 247–53. https://doi.org/10.1111/j.1540-8175.2008.00806.x.
Diaz T, Pencina MJ, Benjamin EJ, Aragam J, Fuller DL, Pencina KM, et al. Prevalence, clinical correlates, and prognosis of discrete upper septal thickening on echocardiography: the Framingham Heart Study. Echocardiography. 2009 Mar;26(3):247–53.
Diaz, Tulio, et al. “Prevalence, clinical correlates, and prognosis of discrete upper septal thickening on echocardiography: the Framingham Heart Study.Echocardiography, vol. 26, no. 3, Mar. 2009, pp. 247–53. Pubmed, doi:10.1111/j.1540-8175.2008.00806.x.
Diaz T, Pencina MJ, Benjamin EJ, Aragam J, Fuller DL, Pencina KM, Levy D, Vasan RS. Prevalence, clinical correlates, and prognosis of discrete upper septal thickening on echocardiography: the Framingham Heart Study. Echocardiography. 2009 Mar;26(3):247–253.
Journal cover image

Published In

Echocardiography

DOI

EISSN

1540-8175

Publication Date

March 2009

Volume

26

Issue

3

Start / End Page

247 / 253

Location

United States

Related Subject Headings

  • Statistics as Topic
  • Sensitivity and Specificity
  • Risk Factors
  • Risk Assessment
  • Reproducibility of Results
  • Prognosis
  • Prevalence
  • Middle Aged
  • Massachusetts
  • Male